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Gene-environment interaction influences the reactivity of autoantibodies to citrullinated antigens in rheumatoid arthritis

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Figure 1: Risk of autoantibody-positive disease conferred by HLA-DRB1 shared epitope alleles, smoking and their interaction.

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Contributions

D.v.d.W. performed the ELISA assays, performed statistical analyses, produced the figures, Supplementary Table 1 and Supplementary Note and wrote the paper. W.G.A. performed statistical analyses. W.V. performed the HLA-DRB1 genotyping. R.R.P.d.V. supervised statistical analyses. J.J.H.-D. performed and supervised statistical analyses. T.W.J.H. contributed to the design of the study and the writing of the paper. R.E.M.T. designed the study, supervised the laboratory experiments and contributed to the writing of the paper. All authors contributed to the final paper.

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Supplementary Table 1 and Supplementary Note (PDF 124 kb)

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van der Woude, D., Alemayehu, W., Verduijn, W. et al. Gene-environment interaction influences the reactivity of autoantibodies to citrullinated antigens in rheumatoid arthritis. Nat Genet 42, 814–816 (2010). https://doi.org/10.1038/ng1010-814

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