Elsevier

Mucosal Immunology

Volume 2, Issue 5, September 2009, Pages 403-411
Mucosal Immunology

Article
Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa

https://doi.org/10.1038/mi.2009.100Get rights and content
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Abstract

T helper type 17 (Th17) cells are a distinct lineage of T cells that produce the effector molecules IL-17, IL-17F, IL-21, and IL-22. Although the role of Th17 cells in autoimmunity is well documented, there is growing evidence that the Th17 lineage and other interleukin (IL)-17-producing cells are critical for host defense against bacterial, fungal, and viral infections at mucosal surfaces. Here we summarize recent progress in our understanding of the function of IL-17-producing cells as a bridge between innate and adaptive immunity against infectious diseases at the mucosa.

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Disclosure The author declared no conflict of interest.

Supplementary information The online version of this article (doi:10.1038/mi.2009.100) contains supplementary material, which is available to authorized users.