Mice with mutations in the Mer tyrosine kinase have deficits in the clearance of apoptotic thymocytes and increased titers of anti-DNA autoantibodies. These findings provide new in vivo evidence to suggest that impairments in clearance of apoptotic cells may underlie systemic autoimmunity.
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Rosen, A., Casciola-Rosen, L. Clearing the way to mechanisms of autoimmunity. Nat Med 7, 664–665 (2001). https://doi.org/10.1038/89034
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DOI: https://doi.org/10.1038/89034
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