MiscellaneousShort-Term and Long-Term Outcome of Anti-Jo1-Positive Patients with Anti-Ro52 Antibody
Section snippets
Patients and Methods
This retrospective study began with a search of the institutional centers' medical record index, which provides access to the diagnoses of the centers' patients. The first electronic search involved use of the codes PM and DM to identify patients with a diagnosis of PM/DM seen from January 1995 to January 2010 in 4 academic centers (Lille, Paris, Cochin, and Pitié-Salpêtrière Hospitals, Rouen). The diagnosis of PM/DM was based on the Bohan and Peter criteria (14, 15), as follows: (1) symmetric
General Characteristics of Anti-Jo1-Positive Patients with Anti-Ro52 Antibody
The 36 anti-Jo1-positive patients with anti-Ro52 antibody comprised 11 men and 25 women with a median age of 56 years [range: 20 to 75] at ASS diagnosis. Twenty-four patients had PM and 12 had DM. Thirty-two patients presented with myalgia (88.9%), and 27 exhibited muscle weakness (75%); the median score of muscle power at ASS diagnosis was 68 [range: 49 to 84]. The patients presented ASS-related complications: Raynaud's phenomenon (n = 18), mechanic's hands (n = 20), joint impairment (n = 25),
Discussion
The Ro/SSA antigen was first described in 1962 by Anderson and coworkers (27). It consists of 2 polypeptide components of 52 kDa and 60 kDa; Ro52 is biochemically and immunologically distinct from Ro60, Ro52 having the greatest immunogenicity (4). The Ro52 gene has been mapped to the end of the short arm of chromosome 11, and Ro52 antigen has been identified as a tripartite motif 21 protein (28). The expression of anti-Ro52 antibody is mainly associated with various connective tissue diseases,
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The authors have no conflicts of interest to disclose.