Relapsing polychondritisBiologics in Relapsing Polychondritis: A Literature Review
Section snippets
Methods
A PubMed Medline search was conducted through December 2010 to identify all studies that reported the efficacy and/or safety of biologics in RP. For inclusion, the publication had to be written in English, French, Spanish, Portuguese, or German. The MeSH term “relapsing polychondritis” and subheading “biologics” (and various synonyms) were used. Reference lists of the papers initially detected were manually searched to identify additional relevant reports. Studies had to contain sufficient and
Literature Search Results and Trials Characteristics
Figure 1 shows the process of selection of published trials for this systematic review. The search strategy yielded 30 articles that included 62 patients (3, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41). All publications were case series or isolated case reports. No randomized controlled trial has been performed; therefore, an evaluation of the methodological quality of trials and meta-analysis were impossible.
The patients
Discussion
The etiopathogenesis and causes of flare in RP remain unclear (1, 2). An autoimmune etiology of RP is presumed based on frequent association with autoimmune diseases and presence of HLA-DR4 antigens (5); evidence of CD4+ T-helper cell and B-cell infiltration in inflamed tissues (6, 7, 8); presence of immune complexes in cartilage (8, 9); presence of antibodies to type II collagen (10, 11), antibodies to matrilin, and other antigens in the sera (7, 8, 11); and clinical improvement after
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