CardiovascularAsymptomatic Hyperuricemia and Serum Uric Acid Concentration Correlate with Subclinical Atherosclerosis in Psoriatic Arthritis Patients Without Clinically Evident Cardiovascular Disease1
Section snippets
Patients
A cohort of 52 PsA patients who fulfilled the Moll and Wright criteria (15) without traditional CV risk factors or clinically evident CV disease, followed at the outpatient rheumatology clinic of the Hospital Xeral-Calde, Lugo, Spain, was studied.
These patients formed part of an ongoing study on CV disease in PsA (5, 6, 16). Briefly, from the time of diagnosis of PsA, all patients included in this study were actively treated with nonsteroidal anti-inflammatory drugs (indomethacin 100 mg/d,
Results
The mean serum uric acid level in our 52 PsA patients was 4.9 ± 1.4 mg/dL (median: 4.7 mg/dL; range: 2.2-7.7; interquartile range: 4.0-6.0). Six (11.5%) of the 52 patients fulfilled the definition of HU and all were men. None of the patients included in this series had a history of gout.
The main differences between PsA patients with and without HU are shown in Table 1. Although no significant differences in the age at the onset of PsA or in the duration of the disease were observed, patients
Discussion
In this study we report, for first time, a significant correlation between serum uric acid concentration and subclinical atherosclerosis in PsA patients without clinically evident CV or classic CV risk factors. The distribution of PsA patients into 4 quartiles according to the carotid artery IMT yielded statistically significant differences in the mean serum uric acid levels of these patients; patients with carotid IMT values > 0.90 mm had significantly higher serum uric acid levels than those
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Age and Gender Differences Between Carotid Intima-Media Thickness and Serum Uric Acid
2022, American Journal of CardiologyComorbidities associated with psoriatic arthritis: Review and update
2020, Clinical ImmunologyCardiovascular morbidity and mortality in ankylosing spondylitis and psoriatic arthritis
2018, Best Practice and Research: Clinical RheumatologyCitation Excerpt :Hyperuricemia is associated with increased CV risk. In a small cross-sectional study of patients with PsA, elevated serum uric acid was associated with increased CIMT on ultrasound, suggesting that this association may hold for PsA as well, although larger and prospective studies are currently lacking [91]. Subclinical atherosclerosis is common in PsA and AS.
Cardiovascular disease in inflammatory rheumatic diseases
2016, Best Practice and Research: Clinical RheumatologyCitation Excerpt :Serum uric acid elevation, which is common in psoriasis, is also an independent risk factor for CV morbidity and mortality. A study in PsA patients disclosed an association between the levels of serum uric acid and cIMT values [86]. Serum uric acid is also associated with hypertension and end organ damage in RA [87].
Psoriasis and cardiovascular risk: Immune-mediated crosstalk between metabolic, vascular and autoimmune inflammation
2015, IJC Metabolic and EndocrineCitation Excerpt :The study of a fifty-three -PsA-patient cohort, without CVR factors or clinically evident CVD, has shown a significant correlation between carotid IMT and serum uric acid concentration. Taken together, asymptomatic hyperuricemic PsA patients have been associated with subclinical atherosclerosis [131]. Angiogenesis appears to be pathological in some chronic inflammatory diseases, like Ps and RA.
Cardiovascular risk type in patients with ankylosing spondylitis
2014, Revue du Rhumatisme (Edition Francaise)
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Drs. Gonzalez-Gay, Gonzalez-Juanatey, and Llorca contributed equally to this study.