Quality of lifeAssessing the Impact of Psoriatic Arthritis on Patient Function and Quality of Life: Lessons Learned from Other Rheumatologic Conditions
Section snippets
Methods
The PubMed database and recent meeting abstracts were searched to find articles relevant to the assessment of patient function and HRQOL in PsA and related conditions. The following search terms were included: rheumatoid arthritis, spondyloarthropathy, ankylosing spondylitis, psoriatic arthritis, and psoriasis for title; combined with the terms quality of life, patient-reported outcomes, function, physical, psychosocial, psychological, depression, fatigue, employment, and work for abstract. The
Impact of Disease
Psoriatic arthritis is characterized by inflammatory arthritis and enthesitis occurring in patients with psoriasis. Psoriasis is present in about 1 to 5% of the general population of North America and Europe (4, 5). Extensive telephone surveys of psoriasis patients conducted in the United States and Europe reveal a diagnosis of PsA in 11 to 30% of patients (6, 7). The average age of onset is age 40 years (8), and the condition occurs equally among men and women (9). Clinically, PsA involves
Discussion
A number of recent studies have demonstrated improvements in function and HRQOL with treatment in patients with PsA (Table 5). Most data are derived from major placebo-controlled trials of biologic therapies, but data are also available from 2 trials of nonbiologic agents. Patients with PsA treated with leflunomide 20 mg/d for 24 weeks demonstrated greater improvement in clinical measures, function (HAQ), and quality of life (DLQI) compared with placebo controls (160). Although combination
Acknowledgments
The author thanks Debra Stamper, PhD and Rick Davis, MS, RPh, who provided medical writing services on behalf of Amgen Inc.
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Cited by (24)
Health-related quality of life in early psoriatic arthritis compared with early rheumatoid arthritis and a general population
2021, Seminars in Arthritis and RheumatismCitation Excerpt :Originally developed for RA, the index is now considered a generic tool. HAQ-DI has been shown to correlate with disability in both PsA [24] and RA [23]. HAQ-DI is a good predictor of productivity, morbidity, health care utilization, health care costs, and mortality rates [23], but has limited utility in assessing the dermatological effect of psoriasis.
The psychosocial burden of psoriatic arthritis
2017, Seminars in Arthritis and RheumatismCitation Excerpt :The QoL impairment observed in patients with psoriasis is comparable to that found in individuals with other chronic disease including heart disease, diabetes, cancer, and depression [20]. Additionally, the visibility of psoriasis can result in poor psychosocial function in patients with PsA, causing embarrassment, self-consciousness, and depression [7,21]. Patients feel stigmatized by the disease, reporting feelings of rejection, shame, and guilt [19].
Pain-related musculoskeletal disorders, psychological comorbidity, and the relationship with physical and mental well-being in Gulf War veterans
2014, PainCitation Excerpt :An association between musculoskeletal pain and well-being has been shown in veteran populations (46) as well as community- and clinic-based populations [28,46]. Health and well-being instruments, for example, SF-12, are increasingly used in clinical practice to monitor the impact of MSD interventions [31]. The markedly lower SF-12 PCS scores in those with MSD observed in our study suggest that MSDs have a greater impact on physical health and well-being, and the SF-12 PCS may better discriminate in monitoring health status and recovery, whereas the SF-12 MCS may assist in monitoring mental health recovery in those with MSD and a comorbid psychological disorder.
Dr. Mease has received research grant support, consulting fees, and speaker honoraria from Abbott, Amgen, BiogenIDEC, Bristol Myers Squibb, Centocor, Genentech, and Wyeth. He has received consulting fees from UCB.