Lupus-Associated Pancreatitis
Section snippets
Methods
We describe 3 patients with lupus-associated pancreatitis. In addition, the English literature of the last 30 years was reviewed, following a Medline search using the terms “lupus” and “pancreatitis.” The review included demographic, clinical, therapeutic, and prognostic aspects of patients with SLE pancreatitis. Data from these reports were combined and analyzed using descriptive statistics and further by the Fisher exact test and the Mann–Whitney rank-sum test for nominal and ordinal
Discussion
It is clear that definite conclusions cannot be drawn from such a review of individual cases. It is likely that most often the severe, unusual, or fatal cases are being reported, while cases with mild pancreatitis and complete recovery may not be published. In addition, occasionally details were missing from some of the cases in the literature. Reporting of selected cases and selected data tends to bias the overall clinical picture. As an example, the true mortality rate or complication rate in
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2017, Handbook of Systemic Autoimmune DiseasesCitation Excerpt :Autoimmune pancreatitis related to hyper-IgG4 syndrome has also been reported in lupus patients [35]. The usual clinical manifestations are seen—severe abdominal pain, nausea, and vomiting—but mortality seems higher than in non-SLE–associated pancreatitis [33]. Pancreatitis seems to be more common and severe in pediatric-onset SLE, and mortality is higher, likely in relation to a greater disease activity [36,37].
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Disclosures: None.
Source of support: none.