REGULAR ARTICLEActivation of the Haemostatic System in Children with Juvenile Rheumatoid Arthritis Correlates with Disease Activity
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Patients and Methods
The study comprised 24 children aged from 5 to 17 years with different clinical subtypes of juvenile rheumatoid arthritis according to the classification criteria of the American College of Rheumatology (ACR) [10], (systemic onset arthritis: 4, seronegative chronic polyarthritis: 7, pauciarticular arthritis type I: 4; pauciarticular arthritis type II: 9) and 10 patients with postinfectious arthropathies. Postinfectious arthropathies were defined as nonseptic oligo- or monoarticular affections
Results
F1+2, TAT, D-Dimer, and fibrinogen were significantly elevated in patients with JRA as compared with healthy controls (p<0.001) and patients with postinfectious arthropathies (F1+2: , TAT: , D-Dimer: , fibrinogen: p=0.026). Patients with postinfectious arthropathies showed significantly higher concentrations of F1+2 () and D-Dimer () as compared with controls (Table 1).
Table 2 shows significant correlation between the joint index score, CRP, haemoglobin and F1+2
Discussion
In the present study in JRA patients, a significant elevation of very sensitive haemostatic molecular markers such as F1+2, TAT, and D-Dimer indicates a pronounced activation of the haemostatic system. The elevated haemostatic activation markers correlated significantly with JRA disease activity scores and conventional inflammatory parameters like CRP and haemoglobin.
Alterations of the haemostatic system may contribute to the destructive and fibroproliferative processes in chronic inflammatory
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