Clinical investigations: interventional cardiologyAssessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude☆
Section snippets
Study population
Eighty-nine subjects presenting for evaluation of chest pain gave their written informed consent to participate and underwent simultaneous testing with brachial artery ultrasound scanning (BAUS) imaging and finger plethysmography with PAT. Subjects were instructed to fast starting the night before testing and to refrain from smoking, ingesting alcohol or caffeine, and taking any vasoactive medications the day of testing. Exclusion criteria included recent myocardial infarction or unstable
Study population
Eighty-nine subjects (54 male, 35 female) an average of 54 ± 2 years of age underwent simultaneous testing with PAT and BAUS. Characteristics of this study population are listed in Table I. Subjects had normal left ventricular function (ejection fraction 61% ± 2%), and approximately one third reported a history of CAD. Forty percent of subjects had hypertension, 47% of subjects had hyperlipidemia, and 9% of subjects had diabetes mellitus.
Relation between PAT and BAUS measures
The average PAT hyperemia ratio was 1.5 ± 0.05 (range
Discussion
In this study, we evaluated the ability of changes in PWA during reactive hyperemia to reflect dynamic changes related to peripheral vascular endothelial function. In addition, we sought to determine whether PWA changes are related to factors known to affect endothelial function. These data indicate that there is a significant relationship between hyperemia-induced finger PWA changes, defined as the PAT hyperemia ratio, and brachial artery FMD. The PAT hyperemia ratio was reduced in subjects
Acknowledgements
We thank the staff of the Division of Nuclear Medicine and the Cardiovascular Imaging and Hemodynamics Laboratories at the Tufts-New England Medical Center.
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