Biochemical and Biophysical Research Communications
Age-related changes in linoleate and α-linolenate desaturation by rat liver microsomes
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2019, Prostaglandins Leukotrienes and Essential Fatty AcidsCitation Excerpt :The present study clearly confirms three different effects of FADS polymorphisms (major allele homozygote, heterozygote, and minor allele homozygote) on LCPUFA biosynthesis. Direct measurement of Δ5 and Δ6 desaturase activities in liver microsomes clarified that LCPUFA biosynthetic capacity declines with age in rodents [8,9]. Regarding humans, it is suggested that LCPUFA biosynthesis might also decrease because surrogate desaturase indices, such as ARA/DGLA and DHA/EPA in plasma phospholipid were decreased in elderly women compared with those in younger women [15].
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Fish Oil Supplementation Prevents Age-Related Memory Decline: Involvement of Nuclear Hormone Receptors
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2014, Journal of Dairy ScienceCitation Excerpt :Nulliparous dams had greater desaturase indices for C20:4n-6, C20:5n-3, and C22:6n-3 (Table 4) compared with parous dams (P < 0.01), demonstrating less ability to synthesize essential FA derivatives by older cows. In rats, overall Δ6-desaturase activity was depressed with age (Hrelia et al., 1989). This would suggest that offspring born to first-lactation cows may have better development of their central nervous systems.
Thirst deficits in aged rats are reversed by dietary omega-3 fatty acid supplementation
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