Pulmonary diffusing capacity disturbances are related to nailfold capillary changes in patients with Raynauds's phenomenon with and without an underlying connective tissue disease
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Diagnostic significance of nailfold capillary patterns in patients with Raynaud's phenomenon
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Impaired carbon monoxide diffusing capacity as a marker of limited systemic sclerosis
2011, European Journal of Internal MedicineCitation Excerpt :DLCO therefore reflects the underlying pulmonary vasculopathy [5] and is a well-known major predictive factor and early marker of PAH [1,2,4,6,7]. DLCO impairment has also been linked to altered nailfold capillary microscopy (NCM) findings in SSc patients with RP [8]. Along with NCM, anti-nuclear antibodies are the most sensitive predictor of the transition from idiopathic RP (iRP) to RP secondary to connective tissue disease [9–11].
Pulmonary function tests in interstitial lung disease: What role do they have?
2001, Clinics in Chest MedicineCitation Excerpt :Although the course of fibrosing alveolitis complicating PSSc is usually indolent, some patients exhibit a more rapid course. Factors associated with a deteriorating course and increased risk for pulmonary hypertension include peripheral vascular involvement, digital pitting or ulcerations, severe Raynaud's phenomenon, and a history of smoking.137,256 The presence of increased neutrophils on BAL (a surrogate marker of alveolitis) has been associated with an accelerated loss of lung function304,356 and more extensive fibrosis on HRCT scan.345
Serial nailfold capillary microscopy in primary Raynaud's phenomenon and scleroderma
1994, Seminars in Arthritis and RheumatismPulmonary function in systemic lupus erythematosus is related to distinct clinical, serologic, and nailfold capillary patterns
1992, The American Journal of MedicineClinical associations of antiribonucleoprotein antibodies in patients with systemic lupus erythematosus
1990, Seminars in Arthritis and Rheumatism