Cerebrovascular disease and antiphospholipid antibodies in systemic lupus erythematosus, lupus-like disease, and the primary antiphospholipid syndrome☆
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Cited by (328)
Clinical presentation of antiphospholipid syndrome
2021, Lahita’s Systemic Lupus ErythematosusBilateral central retinal artery occlusion in a patient with systemic lupus erythematosus
2015, Journal of Stroke and Cerebrovascular DiseasesCitation Excerpt :Stroke is prevalent in 2%-15% SLE patients.8 The presence of lupus anticoagulant and anticardiolipin antibodies in SLE patient is associated with a higher risk of developing severe vaso-occlusive retinopathy2,9 and ischemic infarction.10 Nevertheless, in one study, the prevalence of lupus anticoagulant and anticardiolipin antibodies was similar in SLE patients with ischemic infarction, and the most common type of ischemic infarction was small-vessel disease among SLE patients.11
The risk of ischemic stroke in major rheumatic disorders
2014, Journal of NeuroimmunologyCitation Excerpt :This finding highlights hypertension as a potent IS risk factor in SLE, although management of coexisting conventional risk factors may differ in scope from one geographic region to another. The presence of APA in SLE is strongly associated with IS (Asherson et al., 1989). An analysis of 29 published series (covering over 1000 patients with SLE) yielded an average prevalence of 34% for lupus anticoagulant (LAC) and 44% for anticardiolipin antibodies (ACL) (Love and Santoro, 1990).
Endosomal vesicles as vehicles for viral genomes
2014, Trends in Cell BiologyCitation Excerpt :Autoantibodies against BMP result in autoimmune disorders such as antiphospholipid syndrome and Niemann–Pick type C syndrome. Anti-BMP antibodies cause dysfunctional sorting and trafficking in LEs [20,21], suggesting a critical role for BMP in LE function and dynamics. Recent evidence suggests that these changing lipid compositions in endosomes, combined with the pH threshold of fusion, may direct virus entry to specific points along the endocytic pathway.
Neuropsychiatric Lupus: The Prevalence and Autoantibody Associations Depend on the Definition: Results from the 1000 Faces of Lupus Cohort
2012, Seminars in Arthritis and RheumatismThrombophilic screening in young patients (< 40 years) with idiopathic ischemic stroke: A controlled study
2011, Thrombosis ResearchCitation Excerpt :It is worth pointing out that 21 out of 34 (61.7%) patients had an abnormal pathologic value to at least one of the used specific tests for the determination of the APA. An association between ischemic stroke and the presence of APA has been reported in retrospective [9,10] and in prospective controlled studies [11–14]. Patients with ischemic stroke and APA are younger than the general stroke population, even if this association in older patients has been recently reported [10,13,14].
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This work was supported by the British SLE Aids Group, Jean Sahankz Foundation, and the Caja be Madrid.