Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis

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Abstract

Possible associations between HLA-DR4 and laboratory, radiographic, joint count, functional, and demographic measures of clinical status were analyzed in 154 white patients with rheumatoid arthritis. Overall, 65 percent of the patients were HLA-DR4 positive, similar to other series. HLA-DR4 was associated significantly with the presence of rheumatoid factor and more severe radiographic changes. HLA-DR4 was not associated with significant differences in demographic, joint count, or functional measures of clinical status. HLA-DR1 was not associated significantly with differences in the presence of rheumatoid factor, radiographic changes, or other measures of clinical status. Selective associations of HLA-DR4 with rheumatoid factor and radiographic scores were more marked in men than in women. Patients who were putatively homozygous for HLA-DR4 were all seropositive and had more severe radiographic changes than patients who were heterozygous for HLA-DR4.

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  • This work was supported in part by National Institutes of Health General Clinical Research Centers grant 5M01RR00095, NIH grant AM-21393 to the American Rheumatism Association Medical Information System, the Jack C. Massey Foundation, Robert Wood Johnson Foundation, Arthritis Foundation, and the Maury County Lupus Fund.

    Current address: Division of Transplant Immunology, Department of Medicine, University of Texas Health Science Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75235.

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