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Share Epitope, Citrullinated Cyclic Peptide Antibodies and Smoking in Brazilian Rheumatoid Arthritis Patients

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Abstract

The events involved in the pathogenesis of rheumatoid arthritis (RA) still remain unclear, but certainly the etiology is multifactorial. Shared epitope (SE) of HLADRβ1 is the most important genetic risk factor. Environmental risk factors are less understood. Smoking is a candidate, associated with the rising of citrullinated cyclic peptide antibodies (anti-CCP). Anti-CCP antibodies are highly specific for RA. In this study, we investigated whether the association between anti-CCP production and smoking was influenced by carriage of SE in a highly miscegenated population of patients with RA. One hundred Brazilian patients were inquired about cigarette smoking. For all of them, DNA for HLA typing and serum to anti-CCP antibodies quantification were obtained. Forty-two were smokers and 58 were nonsmokers. The SE was present in 61 patients and the anti-CCP was positive in 71 patients. We found that, among smokers, 25 were SE-positive, 22 presented with anti-CCP and 3 without anti-CCP, and 17 were SE-negative, 9 presented with anti-CCP and 8 without anti-CCP (OR 6.5, 95% CI 1.40 to 30.20). These results suggest that environmental factors contribute to the raising of anti-CCP in individuals with HLA background to RA, smoking being a strong candidate.

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Authors and Affiliations

  1. Division of Clinical Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

    Rene Donizeti Oliveira, Cristina Maria Junta, Fabíola Reis Oliveira, Lucienir Maria Silva, Eduardo Antonio Donadi & Paulo Louzada-Junior

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  1. Rene Donizeti Oliveira
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  2. Cristina Maria Junta
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  3. Fabíola Reis Oliveira
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  4. Lucienir Maria Silva
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  5. Eduardo Antonio Donadi
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  6. Paulo Louzada-Junior
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Correspondence to Paulo Louzada-Junior.

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Oliveira, R.D., Junta, C.M., Oliveira, F.R. et al. Share Epitope, Citrullinated Cyclic Peptide Antibodies and Smoking in Brazilian Rheumatoid Arthritis Patients. Clinic Rev Allerg Immunol 34, 32–35 (2008). https://doi.org/10.1007/s12016-007-8017-2

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