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Is Psoriatic Arthritis a Result of Abnormalities in Acquired or Innate Immunity?

  • PSORIATIC ARTHRITIS (O FITZGERALD AND P HELLIWELL, SECTION EDITORS)
  • Published:
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Abstract

Psoriatic arthritis is a common chronic inflammatory joint disease in which both inflammation and tissue damage contribute to the patient’s outcome. Abnormal activation of the innate and the adaptive immune system contributes to the chronic disease process. Novel insights into these immune pathways are further corroborated by genetic evidence. In this review, we compare the current paradigm of psoriasis to mechanisms that likely play a role in psoriatic arthritis and provide an overview of the role of immune mechanisms in the different features of the disease.

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Disclosure

Dr. Lories has served as a consultant for Pfizer, Abbott Laboratories, Merck & Co., and Celgene Corp.; has received grant support from Pfizer and Abbott Laboratories; has received payment for development of educational presentations (including service on speakers’ bureaus) from Merck & Co. and UCB; and has had travel/accommodations expenses covered/reimbursed by Abbott Laboratories and Merck & Co.

Dr. de Vlam reported no potential conflicts of interest relevant to this article.

Dr. Lories and Dr. de Vlam are holders of the KU Leuven Abbott Chair for Psoriatic Arthritis Research.

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Authors and Affiliations

  1. Laboratory for Skeletal Development and Joint Disorders, Department of Development and Regeneration, KU Leuven, Herestraat 49, 300, Leuven, Belgium

    Rik J. Lories

  2. Department of Rheumatology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium

    Rik J. Lories & Kurt de Vlam

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  1. Rik J. Lories
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  2. Kurt de Vlam
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Correspondence to Rik J. Lories.

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Lories, R.J., de Vlam, K. Is Psoriatic Arthritis a Result of Abnormalities in Acquired or Innate Immunity?. Curr Rheumatol Rep 14, 375–382 (2012). https://doi.org/10.1007/s11926-012-0257-3

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  • DOI: https://doi.org/10.1007/s11926-012-0257-3

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