Skip to main content
SpringerLink
Log in

The SLICC inception cohort for atherosclerosis

  • Published:
Current Rheumatology Reports Aims and scope Submit manuscript

Abstract

The Systemic Lupus Erythematosus International Collaborating Clinics (SLICC) is a group of rheumatologists and methodologists from 27 international centers who have a particular interest and expertise in systemic lupus erythematosus. Initially, its efforts focused on development and validation of disease activity and damage indices. In 2000, the SLICC Registry for Atherosclerosis was established to determine the incidence, prevalence, nature, and risk factors of atherosclerotic coronary artery disease in systemic lupus erythematosus. Risk factors for coronary artery disease at presentation to the cohort were reported, as well as their accumulation over the first few years. Development of the metabolic syndrome was also described. Among the first 1078 patients who entered the cohort, 61 vascular events have occurred in 47 patients who were older at diagnosis and more likely male and hypertensive than were the patients without vascular events. Additional studies using this cohort are ongoing.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References and Recommended Reading

  1. Isenberg DA, Gladman D: The Systemic Lupus International Collaborating Clinics Group—origins and outcomes. Lupus 2001, 10: 375–377.

    Article  PubMed  CAS  Google Scholar 

  2. Isenberg D, Bacon P, Bombardier C, et al.: Criteria for assessing disease activity in systemic lupus erythematosus. J Rheumatol 1989, 16: 1395–1396.

    PubMed  CAS  Google Scholar 

  3. Gladman DD, Goldsmith CH, Urowitz MB, et al.: Crosscultural validation of 3 disease activity indices in systemic lupus erythematosus. J Rheumatol 1992, 19: 608–611.

    PubMed  CAS  Google Scholar 

  4. Gladman DD, Goldsmith CH, Urowitz MB, et al.: Sensitivity to change of 3 systemic lupus erythematosus disease activity indices: international validation. J Rheumatol 1994, 21: 1468–1471.

    PubMed  CAS  Google Scholar 

  5. Gladman D, Ginzler E, Goldsmith C, et al.: Workshop report—Systemic lupus international collaborative clinics: development of a damage index in systemic lupus erythematosus. J Rheumatol 1992, 19: 1820–1821.

    PubMed  CAS  Google Scholar 

  6. Gladman D, Ginzler E, Goldsmith C, et al.: The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index for systemic lupus erythematosus. Arthritis Rheum 1996, 39: 363–369.

    Article  PubMed  CAS  Google Scholar 

  7. Gladman D, Urowitz MB, Goldsmith C, et al.: The reliability of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index in patients with systemic lupus erythematosus. Arthritis Rheum 1997, 40: 809–813.

    Article  PubMed  CAS  Google Scholar 

  8. Gladman DD, Goldsmith C, Urowitz M, et al.: The Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index for Systemic Lupus Erythematosus International Comparison. J Rheumatol 2000, 17: 373–376.

    Google Scholar 

  9. Isenberg D, Petri M, Goldsmith C, et al.: Systemic Lupus Erythematosus International Collaborating Clinics (SLICC) conference on assessment of lupus flare and quality of life measures in SLE. Systemic Lupus International Collaborating Clinics Group. J Rheumatol 1996, 23: 1953–1955.

    PubMed  Google Scholar 

  10. Manzi S, Meilahn EN, Rairie JE, et al.: Age-specific incidence rates of myocardial infarction and angina in women with systemic lupus erythematosus: comparison with the Framingham Study. Amer J Epidemiol 1997, 145: 408–415.

    CAS  Google Scholar 

  11. Petri M, Perez-Gutthan S, Spence D, et al.: Risk factors for coronary artery disease in patients with systemic lupus erythematosus. Amer J Med 1992, 93: 513–519.

    Article  PubMed  CAS  Google Scholar 

  12. Gladman DD, Urowitz MB: Morbidity in systemic lupus erythematosus. J Rheumatol 1987, 14(Suppl 13): 223–226.

    Google Scholar 

  13. Manzi S, Selzer F, Sutton-Tyrrel K, et al.: Prevalence and risk factors of carotid plaque in women with systemic lupus erythematosus. Arthritis Rheum 1999, 42: 51–60.

    Article  PubMed  CAS  Google Scholar 

  14. Gladman DD, Ibañez D, Urowitz MB: Systemic lupus erythematosus disease activity index 2000. J Rheumatol 2002, 29: 288–291.

    PubMed  Google Scholar 

  15. Urowitz MB, Gladman D, Ibañez D, et al.: Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: data from an international inception cohort. Lupus 2007, 16: 1731–1735.

    Google Scholar 

  16. Urowitz MB, Gladman D, Ibañez D, et al.; Systemic Lupus International Collaborating Clinics: Accumulation of coronary artery disease risk factors over 3 years: data from an international inception cohort. Arthritis Rheum 2008, 59: 176–180.

    Article  PubMed  CAS  Google Scholar 

  17. Urowitz MB, Gladman DD, Ibañez D, et al.: Accumulation of atherosclerotic risk factors over 3 years by ethnicity in an international inception cohort. Arthritis Rheum 2006, 54(Suppl 9): S455.

    Google Scholar 

  18. Rahman P, Urowitz MB, Gladman DD, et al.: Contribution of traditional risk factors to coronary artery disease in patients with systemic lupus erythematosus. J Rheumatol 1999, 26: 2363–2368.

    PubMed  CAS  Google Scholar 

  19. Esdaile JM, Abrahamowicz M, Grodzicky T, et al.: Traditional Framingham risk factors fail to fully account for accelerated atherosclerosis in systemic lupus erythematosus. Arthritis Rheum 2001, 44: 2331–2337.

    Article  PubMed  CAS  Google Scholar 

  20. Urowitz MB, Gladman DD, Ibañez D, et al.: Disease outcomes in the first 4 years of systemic lupus erythematosus: results from the SLICC inception cohort. Arthritis Rheum 2007, 56(Suppl 9): S454.

    Google Scholar 

  21. Urowitz MB, Gladman DD, Fortin PR, et al.: Systemic Lupus International Collaborating Clinics (SLICC) inception cohort registry to study risk for atherosclerosis: metabolic syndrome, prevalence and associated factors. Arthritis Rheum 2006, 54(Suppl 9): S282.

    Google Scholar 

  22. Urowitz MB, Gladman DD, Ibañez D, et al.: Atherosclerotic vascular events in a multinational inception cohort of SLE: description and attribution. Arthritis Rheum 2007, 56(Suppl 9): S821.

    Google Scholar 

  23. Hanly JG, Urowitz MB, Sanchez-Guerrero J, et al.: Neuropsychiatric events at the time of diagnosis of systemic lupus erythematosus: an international inception cohort study. Arthritis Rheum 2007, 56: 265–273.

    Article  PubMed  CAS  Google Scholar 

  24. Hanly JG, Urowitz MB, Siannis F, et al.: Autoantibodies and neuropsychiatric events at the time of systemic lupus erythematosus diagnosis: Results from an international cohort study. Arthritis Rheum 2008, 58: 843–853.

    Article  PubMed  CAS  Google Scholar 

  25. Bernatsky S, Ramsey-Goldman R, Boivin JF, et al.: An international cohort study of cancer in systemic lupus erythematosus. Arthritis Rheum 2005, 52: 1481–1490.

    Article  PubMed  CAS  Google Scholar 

  26. Bernatsky S, Boivin JF, Joseph L, et al.: Race/ethnicity and cancer occurrence in systemic lupus erythematosus. Arthritis Rheum 2005, 53: 781–784.

    Article  PubMed  CAS  Google Scholar 

  27. Bernatsky S, Ramsey-Gordon R, Rajan R, et al.: Non-Hodgkin’s lymphoma in systemic lupus erythematosus. Ann Rheum Dis 2005, 64: 1507–1509.

    Article  PubMed  CAS  Google Scholar 

  28. Bernatsky S, Boivin JF, Joseph L, et al.: The relationship between cancer and medication exposures in systemic lupus erythematosus: a case-cohort study. Ann Rheum Dis 2008, 67: 74–79.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Toronto Lupus Clinic, Toronto, Canada

    Murray B. Urowitz

  2. Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Room 1E-409, 399 Bathurst Street, Toronto, ON, Canada, M5T 2S8

    Murray B. Urowitz

Authors
  1. Murray B. Urowitz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dafna D. Gladman
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Murray B. Urowitz.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Urowitz, M.B., Gladman, D.D. The SLICC inception cohort for atherosclerosis. Curr Rheumatol Rep 10, 281–285 (2008). https://doi.org/10.1007/s11926-008-0045-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11926-008-0045-2

Keywords

Search

Navigation