Skip to main content

Advertisement

Log in

Celiac Disease Prevalence in Brazilian Dilated Cardiomyopathy Patients

  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

Celiac disease (CD) is a permanent condition of gluten intolerance and a number of autoimmune diseases have been associated with it. In the past few years, a relation between CD and dilated cardiomyopathy (CM) was described in Europe and United States. The aim of this study was to evaluate the prevalence of CD among south Brazilian precardiac transplant patients with advanced CM. A total of 74 patients on a list for heart transplantation were evaluated for the presence CD. The presence of anti-endomisial antibody (IgA-EmA) was determined by indirect immunofluorescence and for the anti-transglutaminase antibody (IgA anti–h-tTG) by ELISA. Serologically positive patients were submitted to upper endoscopy with intestinal biopsy. Two individuals (2.63%) were positive for IgA-EmA and 5 (6.75%) for IgA anti–h-tTG; 1 (1.35%) had both tests positive. Histologic confirmation of CD occurred only in the IgA-EmA positive patients. In conclusion, data from the present study allows recommend the screening for CD in patients with CM using IgA-EmA test as the method of choice.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. King AL, Ciclitira PJ: Celiac disease: strongly heritable, oligogenic but genetically complex. Mol Genet Metab 71:70–75, 2000

    Article  PubMed  CAS  Google Scholar 

  2. Shuppan D: Current concepts of celiac disease pathogenesis. Gastroenterol 119:234–242, 2000

    Article  Google Scholar 

  3. Sollid LM: Molecular basis of celiac disease. Annu Rev Immunol 18:53–81, 2000

    Article  PubMed  CAS  Google Scholar 

  4. Kotze LMS: Doença Celíaca. In Aparelho Digestivo. Clínica e Cirurgia, 3rd ed. JCU Coelho (ed). São Paulo, Atheneu, 2005, pp 703– 724

  5. Mulder CJ, Hadithi MM, Rostami K, Goerres MS: Coeliac disease—has the time come for routine mass screening?In 2002—2010—2020?Rom J Gastroenterol 11:179–182, 2002

    PubMed  Google Scholar 

  6. Pascu O, Dobru D, Tanta M, et al.: The prevalence of coeliac disease at endoscopy units in Romania: routine biopsies during gastroscopy are mandatory (a multicenter study). Rom J Gastroenterol 12:97–100, 2003

    Article  PubMed  Google Scholar 

  7. Vjero K, Martucci S, Alvisi C, et al.: Defining a proper setting for endoscopy in coeliac disease$. $Eur J Gastroenterol Hepatol 15:675–678, 2003

    Article  PubMed  Google Scholar 

  8. Sblattero D, Berti I, Trevisiol C: Human recombinant tissue transglutaminase ELISA: an innovative diagnostic assay for celiac disease. Am J Gastroenterol 95:1253–1257, 2000

    Article  PubMed  CAS  Google Scholar 

  9. Kotze LMS, Utiyama SRR, Nisihara RM, Camargo VF, Ioshii SO: IgA class anti-endomysial and anti-tissue transglutaminase antibodies in relation to duodenal mucosa changes in coeliac disease. Pathology 35:56–60, 2003

    Article  PubMed  Google Scholar 

  10. Cooke WT, Holmes GKT: Coeliac disease. London, Churchill Livingstone, 1984

  11. Logan RFA: Epidemiology of coeliac disease. In Coeliac disease. Marsh MN (ed). Oxford, Blackwell Scientific, 1992, pp 192–194

  12. Collin P, Reunala T, Pukkala E, Laippala P, Keyrilainen O, Pasternack A: Coeliac disease associated disorders and survival. Gut 35:1215–1218, 1994

    PubMed  CAS  Google Scholar 

  13. Cronin CC, Shanahan F: Insulin-dependent diabetes mellitus and coeliac disease. Lancet 349:1096–1097, 1997.

    Article  PubMed  CAS  Google Scholar 

  14. Kingham JG, Parker DR: The association between primary biliary cirrhosis and coeliac disease: a study of relative prevalences. Gut 42:120–122, 1998

    Article  PubMed  CAS  Google Scholar 

  15. Shuppan D, Ciccocioppo R: Coeliac disease and secondary autoimmunity. Dig Liv Dis 34:13–15, 2002

    Article  Google Scholar 

  16. Chimenti C, Pieroni M, Frustac IA: Celiac disease in idiopathic dilated cardiomyopathy. Ital Heart J 2:658–659, 2001

    PubMed  CAS  Google Scholar 

  17. Curiore M, Barbato M, De Biase L, Viola F, Lo Russo L, Cardi E: Prevalence of coeliac disease in idiopathic dilated cardiomyopathy. Lancet 354:222–223, 1999

    Article  Google Scholar 

  18. Fonager K, Sorensen HT, Norgard B, Thulstrup AM: Cardiomyopathy in Danish patients with coeliac disease. Lancet 354:1561, 1999

    Article  PubMed  CAS  Google Scholar 

  19. Frustaci A, Cuoco L, Chimenti C, et al.: Celiac disease associated with autoimmune myocarditis. Circulation 6:2611–2618, 2002

    Article  Google Scholar 

  20. Prati D, Bardella MT, Peracchi M, et al.: High frequency of anti-endomysial reactivity in candidates to heart transplant. Dig Liver Dis 34:39–43, 2002

    Article  PubMed  CAS  Google Scholar 

  21. Randall NW, Machdoom ZA: Dilated cardiomyopathy due to anticardiolipin syndrome in association with celiac sprue. J Clin Gastroenterol 31:91–92, 2000

    Article  PubMed  Google Scholar 

  22. Toutain F, Le Luyer B, Lebas A, Duquenoy A: Maladie coelique et myocardite: une association fortuite?Archives de Pèdiatrie 10:834–835, 2003

    Article  PubMed  Google Scholar 

  23. Richardson P, Mckenna WJ, Bristow M: Report of the 1995 World Organization/International Society and Federation of Cardiology Task Force on the definition and classification of cardiomyopathies. Circulation 93:841–842, 1996

    PubMed  CAS  Google Scholar 

  24. Marsh MN: Mucosal pathology in gluten sensitivity. In Coeliac disease. Marsh MN (ed). Oxford, Blackwell Scientific, 1992, pp 136–191

  25. Volta U, Molinaro N, De Franceschi L, Fratangelo D, Bianchi FB: IgA anti-endomysial antibodies on human umbilical cord tissue for celiac disease screening. Dig Dis Sci 40:1902–1905, 1995

    Article  PubMed  CAS  Google Scholar 

  26. Farrell RJ, Kelly CP: Celiac sprue. N Engl J Med 346:180–188, 2002

    Article  PubMed  CAS  Google Scholar 

  27. Gandolfi L, Pratesi R, Córdoba JC, Tauil PL, Gasparin M: Prevalence of celiac disease among blood donors in Brazil. Am J Gastroenterol 95:689–692, 2000

    Article  PubMed  CAS  Google Scholar 

  28. Nisihara RM, Utiyama SRR, Kotze LMS, Mocelin V: Serologic investigation of celiac disease in southern area from Brazil. Arq Gastroenterol 2005 (in press)

  29. Ferreira M, Davies SL, Butler M, Scott D, Clark M, Kumar P: Endomysial antibody: is the best screening test for coeliac disease?Gut 33:1633–1637, 1992

    PubMed  CAS  Google Scholar 

  30. Meuwisse GW: Diagnostic criteria in coeliac disease. Acta Pediatr Scand 59:461–463, 1969

    Google Scholar 

  31. Kotze LMS, Utiyama SRR, Nisihara RM, Zeni MPB, Sena MG, Amarante HMBS: antiendomysium antibodies in Brazilian patients with celiac disease and their first-degree relatives. Arq Gastroenterol 38:94–103, 2001

    Article  PubMed  CAS  Google Scholar 

  32. Utiyama SRR, Kotze LMS, Nisihara RM, et al.: Spectrum of autoantibodies in celiac patients and relatives. Dig Dis Sci 46:2624–2630, 2001

    Article  Google Scholar 

  33. Not T, Faleschini E, Tommasini A, et al.: Celiac disease in patients with sporadic and inherited cardiomyopathies and in their relatives. Eur Heart J 24:1455–1461, 2003

    Article  PubMed  Google Scholar 

  34. Barbato M, Curiore M, De Biase L, Viola F, Cucchiara S: Idiopathic dilated cardiomyopathy associated with coeliac disease: the effect of a gluten-free diet on cardiac performance. Dig Liv Dis 34:866–869, 2002

    Article  Google Scholar 

  35. Peracchi M, Trovato C, Longhi M, et al.: Tissue transglutaminase antibodies in patients with end-stage heart failure. Am J Gastroenterol 97:2850–2854, 2002

    Article  PubMed  CAS  Google Scholar 

  36. Utiyama SRR, Kotze LMS, Nisihara RM, Camargo VF: Correlação dos anticorpos antiendomísio e antitransglutaminase com a doença celíaca. RBAC 34:39–45, 2002

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ricardo Schmit T De Bem MD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

De Bem, R.S.T., Da Ro Sa Utiyama, S.R., Nisihara, R.M. et al. Celiac Disease Prevalence in Brazilian Dilated Cardiomyopathy Patients. Dig Dis Sci 51, 1016–1019 (2006). https://doi.org/10.1007/s10620-006-9337-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10620-006-9337-4

Key Words

Navigation