Abstract
Celiac disease (CD) is a permanent condition of gluten intolerance and a number of autoimmune diseases have been associated with it. In the past few years, a relation between CD and dilated cardiomyopathy (CM) was described in Europe and United States. The aim of this study was to evaluate the prevalence of CD among south Brazilian precardiac transplant patients with advanced CM. A total of 74 patients on a list for heart transplantation were evaluated for the presence CD. The presence of anti-endomisial antibody (IgA-EmA) was determined by indirect immunofluorescence and for the anti-transglutaminase antibody (IgA anti–h-tTG) by ELISA. Serologically positive patients were submitted to upper endoscopy with intestinal biopsy. Two individuals (2.63%) were positive for IgA-EmA and 5 (6.75%) for IgA anti–h-tTG; 1 (1.35%) had both tests positive. Histologic confirmation of CD occurred only in the IgA-EmA positive patients. In conclusion, data from the present study allows recommend the screening for CD in patients with CM using IgA-EmA test as the method of choice.
Similar content being viewed by others
References
King AL, Ciclitira PJ: Celiac disease: strongly heritable, oligogenic but genetically complex. Mol Genet Metab 71:70–75, 2000
Shuppan D: Current concepts of celiac disease pathogenesis. Gastroenterol 119:234–242, 2000
Sollid LM: Molecular basis of celiac disease. Annu Rev Immunol 18:53–81, 2000
Kotze LMS: Doença Celíaca. In Aparelho Digestivo. Clínica e Cirurgia, 3rd ed. JCU Coelho (ed). São Paulo, Atheneu, 2005, pp 703– 724
Mulder CJ, Hadithi MM, Rostami K, Goerres MS: Coeliac disease—has the time come for routine mass screening?In 2002—2010—2020?Rom J Gastroenterol 11:179–182, 2002
Pascu O, Dobru D, Tanta M, et al.: The prevalence of coeliac disease at endoscopy units in Romania: routine biopsies during gastroscopy are mandatory (a multicenter study). Rom J Gastroenterol 12:97–100, 2003
Vjero K, Martucci S, Alvisi C, et al.: Defining a proper setting for endoscopy in coeliac disease$. $Eur J Gastroenterol Hepatol 15:675–678, 2003
Sblattero D, Berti I, Trevisiol C: Human recombinant tissue transglutaminase ELISA: an innovative diagnostic assay for celiac disease. Am J Gastroenterol 95:1253–1257, 2000
Kotze LMS, Utiyama SRR, Nisihara RM, Camargo VF, Ioshii SO: IgA class anti-endomysial and anti-tissue transglutaminase antibodies in relation to duodenal mucosa changes in coeliac disease. Pathology 35:56–60, 2003
Cooke WT, Holmes GKT: Coeliac disease. London, Churchill Livingstone, 1984
Logan RFA: Epidemiology of coeliac disease. In Coeliac disease. Marsh MN (ed). Oxford, Blackwell Scientific, 1992, pp 192–194
Collin P, Reunala T, Pukkala E, Laippala P, Keyrilainen O, Pasternack A: Coeliac disease associated disorders and survival. Gut 35:1215–1218, 1994
Cronin CC, Shanahan F: Insulin-dependent diabetes mellitus and coeliac disease. Lancet 349:1096–1097, 1997.
Kingham JG, Parker DR: The association between primary biliary cirrhosis and coeliac disease: a study of relative prevalences. Gut 42:120–122, 1998
Shuppan D, Ciccocioppo R: Coeliac disease and secondary autoimmunity. Dig Liv Dis 34:13–15, 2002
Chimenti C, Pieroni M, Frustac IA: Celiac disease in idiopathic dilated cardiomyopathy. Ital Heart J 2:658–659, 2001
Curiore M, Barbato M, De Biase L, Viola F, Lo Russo L, Cardi E: Prevalence of coeliac disease in idiopathic dilated cardiomyopathy. Lancet 354:222–223, 1999
Fonager K, Sorensen HT, Norgard B, Thulstrup AM: Cardiomyopathy in Danish patients with coeliac disease. Lancet 354:1561, 1999
Frustaci A, Cuoco L, Chimenti C, et al.: Celiac disease associated with autoimmune myocarditis. Circulation 6:2611–2618, 2002
Prati D, Bardella MT, Peracchi M, et al.: High frequency of anti-endomysial reactivity in candidates to heart transplant. Dig Liver Dis 34:39–43, 2002
Randall NW, Machdoom ZA: Dilated cardiomyopathy due to anticardiolipin syndrome in association with celiac sprue. J Clin Gastroenterol 31:91–92, 2000
Toutain F, Le Luyer B, Lebas A, Duquenoy A: Maladie coelique et myocardite: une association fortuite?Archives de Pèdiatrie 10:834–835, 2003
Richardson P, Mckenna WJ, Bristow M: Report of the 1995 World Organization/International Society and Federation of Cardiology Task Force on the definition and classification of cardiomyopathies. Circulation 93:841–842, 1996
Marsh MN: Mucosal pathology in gluten sensitivity. In Coeliac disease. Marsh MN (ed). Oxford, Blackwell Scientific, 1992, pp 136–191
Volta U, Molinaro N, De Franceschi L, Fratangelo D, Bianchi FB: IgA anti-endomysial antibodies on human umbilical cord tissue for celiac disease screening. Dig Dis Sci 40:1902–1905, 1995
Farrell RJ, Kelly CP: Celiac sprue. N Engl J Med 346:180–188, 2002
Gandolfi L, Pratesi R, Córdoba JC, Tauil PL, Gasparin M: Prevalence of celiac disease among blood donors in Brazil. Am J Gastroenterol 95:689–692, 2000
Nisihara RM, Utiyama SRR, Kotze LMS, Mocelin V: Serologic investigation of celiac disease in southern area from Brazil. Arq Gastroenterol 2005 (in press)
Ferreira M, Davies SL, Butler M, Scott D, Clark M, Kumar P: Endomysial antibody: is the best screening test for coeliac disease?Gut 33:1633–1637, 1992
Meuwisse GW: Diagnostic criteria in coeliac disease. Acta Pediatr Scand 59:461–463, 1969
Kotze LMS, Utiyama SRR, Nisihara RM, Zeni MPB, Sena MG, Amarante HMBS: antiendomysium antibodies in Brazilian patients with celiac disease and their first-degree relatives. Arq Gastroenterol 38:94–103, 2001
Utiyama SRR, Kotze LMS, Nisihara RM, et al.: Spectrum of autoantibodies in celiac patients and relatives. Dig Dis Sci 46:2624–2630, 2001
Not T, Faleschini E, Tommasini A, et al.: Celiac disease in patients with sporadic and inherited cardiomyopathies and in their relatives. Eur Heart J 24:1455–1461, 2003
Barbato M, Curiore M, De Biase L, Viola F, Cucchiara S: Idiopathic dilated cardiomyopathy associated with coeliac disease: the effect of a gluten-free diet on cardiac performance. Dig Liv Dis 34:866–869, 2002
Peracchi M, Trovato C, Longhi M, et al.: Tissue transglutaminase antibodies in patients with end-stage heart failure. Am J Gastroenterol 97:2850–2854, 2002
Utiyama SRR, Kotze LMS, Nisihara RM, Camargo VF: Correlação dos anticorpos antiendomísio e antitransglutaminase com a doença celíaca. RBAC 34:39–45, 2002
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
De Bem, R.S.T., Da Ro Sa Utiyama, S.R., Nisihara, R.M. et al. Celiac Disease Prevalence in Brazilian Dilated Cardiomyopathy Patients. Dig Dis Sci 51, 1016–1019 (2006). https://doi.org/10.1007/s10620-006-9337-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10620-006-9337-4