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The prognostic factors of systemic sclerosis for survival among Koreans

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Abstract

Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by fibrosis of the skin and internal organs, which can cause significant morbidity and mortality. The prognostic factors for survival were not fully evaluated in Asian population. We investigated the prognostic factors for survival of SSc among Korean patients. A total of 243 SSc patients were enrolled from Seoul National University Hospital between 1972 and 2007. Age at onset, gender, cutaneous subset, autoantibody status, major organ involvement, and occurrence of malignancy were evaluated with all-cause mortality as the end point. A multivariate Cox proportional hazard model was used to retrieve the prognostic factors for survival. During the follow-up of 1,967 person-years, 33 patients died. Old age at onset (hazard ratio [HR] 7.4, 95% confidence interval [95% CI] 1.9–28.1), diffuse cutaneous subset (HR 2.5, 95% CI 1.1–5.9), presence of anti-Scl-70 antibody (HR 3.0, 95% CI 1.2–7.1), forced vital capacity less than 70% (HR 2.8, 95% CI 1.3–6.2), and heart involvement (HR 4.2, 95% CI 1.7–10.2) were found to be significant risk factors for mortality in multivariate analysis. In Korean SSc patients, old age, diffuse cutaneous involvement, anti-Scl-70 antibody, and internal organ involvement are risk factors for mortality.

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Authors and Affiliations

  1. Department of Internal Medicine, Seoul National University College of Medicine, 103 Daehak-Ro, Jongno-Gu, Seoul, 110-744, South Korea

    Jinhyun Kim, Ki Won Moon, Eun Young Lee, Yun Jong Lee, Yeong Wook Song & Eun Bong Lee

  2. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea

    Sue Kyung Park

  3. Department of Immunology, Seoul National University College of Medicine, Seoul, South Korea

    Eun Bong Lee

  4. Medical Research Center, Seoul National University, Seoul, South Korea

    Eun Bong Lee

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  1. Jinhyun Kim
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  2. Sue Kyung Park
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  3. Ki Won Moon
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  4. Eun Young Lee
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  5. Yun Jong Lee
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  6. Yeong Wook Song
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  7. Eun Bong Lee
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Correspondence to Eun Bong Lee.

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Sources of support

This work was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health, Welfare & Family Affairs, Republic of Korea (A030001, A084204).

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Kim, J., Park, S.K., Moon, K.W. et al. The prognostic factors of systemic sclerosis for survival among Koreans. Clin Rheumatol 29, 297–302 (2010). https://doi.org/10.1007/s10067-009-1324-7

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  • DOI: https://doi.org/10.1007/s10067-009-1324-7

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