Abstract
This study aims to investigate the clinical and laboratory features of systemic lupus erythematosus (SLE) patients associated with Sjögren syndrome (SS) in China, as well as its similarities to and differences from SLE patients without SS. A group of 542 consecutive unselected SLE patients was recruited. Diagnosis of SLE was made according to 1997 revised American College of Rheumatology SLE criteria; SS was diagnosed using the American–European classification criteria. Clinical and laboratory parameters in SLE patients with SS (SLE-SS) were compared with those in SLE patients without SS (SLE-no SS). Overall, SS was identified in 35 SLE patients (6.5%); the onset of SS preceded the development of SLE in 17 of them (48.6%). Compared with the SLE-no SS group (35.8 ± 10.5 years), patients with SLE-SS (41.3 ± 11.6 years) were significantly older (P = 0.003), had a higher frequency of anti-Ro/SSA, anti-La/SSB, and anti-dsDNA antibodies, but had a significantly lower frequency of renal involvement. This study demonstrates that SLE-SS may be a subgroup of patients with characteristic clinical and laboratory features. To improve the treatment outcomes in SLE-SS patients, more specific treatment should be applied based on those factors.
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Acknowledgments
This work was supported by grants from the National Natural Science Foundation of China (No. 30571608) and Natural Science Foundation of Anhui Province (No. 070413109). We are indebted to Dr. Boke Zhang, the First Affiliated Hospital of Anhui Medical University, and Dr. Guosheng Wang, Anhui Provincial Hospital, for assistance in case identification. We also thank Wenhui Zhang, Changjuan Xu, and Guoping Chen, students of Anhui Medical University, for assistance in data collection. Their cooperation was invaluable to this research.
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Pan, H.F., Ye, D.Q., Wang, Q. et al. Clinical and laboratory profiles of systemic lupus erythematosus associated with Sjögren syndrome in China: a study of 542 patients. Clin Rheumatol 27, 339–343 (2008). https://doi.org/10.1007/s10067-007-0720-0
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DOI: https://doi.org/10.1007/s10067-007-0720-0