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Malignant thymoma associated with mixed connective tissue disease: a case report

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Abstract

Many autoimmune diseases have been reported to be associated with malignancy. Mixed connective tissue disease (MCTD), however, has rarely been associated with malignancy. Thymoma is one of the neoplasms often reported to be related to various immunological disorders. Among the types of thymoma defined by WHO, malignant thymoma (thymoma type C) is the one least reported to be associated with autoimmune disease. Here, we report a case of malignant thymoma with concurrent MCTD, which manifested with acrosclerosis, Raynaud’s phenomenon, arthritis (synovitis), and a high titer of anti-ribonucleoprotein antibody.

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Authors and Affiliations

  1. Department of Internal Medicine, Rheumatology Unit, Kaohsiung Medical University Hospital, 807, Kaohsiung City, Taiwan (R.O.C.)

    Yu-Chih Lin, Chen-Ching Wu, Tsan-Teng Ou, Jeng-Hsien Yen, Hong-Wen Liu & Wen-Chan Tsai

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  1. Yu-Chih Lin
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  2. Chen-Ching Wu
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  3. Tsan-Teng Ou
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  4. Jeng-Hsien Yen
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  5. Hong-Wen Liu
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  6. Wen-Chan Tsai
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Correspondence to Wen-Chan Tsai.

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Published online: 12 July 2005

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Lin, YC., Wu, CC., Ou, TT. et al. Malignant thymoma associated with mixed connective tissue disease: a case report. Clin Rheumatol 25, 262–264 (2006). https://doi.org/10.1007/s10067-005-1159-9

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  • DOI: https://doi.org/10.1007/s10067-005-1159-9

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