Abstract
We investigated the cause of hereditary periodic fever syndrome in a Spanish child with recurrent long episodes of fever, migratory skin rash, myalgia, arthralgia, conjunctivitis and abdominal pain. Infectious and autoimmune causes were ruled out. No familial history was reported. Analysis of the tumour necrosis factor receptor superfamily 1A ( TNFRSF1A) gene identified a missense mutation (G36E) on exon 3. The absence of this variant in the patient’s parents and in controls identified it as a de novo disease-associated mutation. Clinical symptoms disappeared with administration of etanercept; however, levels of acute-phase reactants remained increased and could not be stabilised by the addition of colchicine. We believe that this patient gained some symptomatic relief with etanercept therapy, although not enough to completely avoid the risk of amyloidosis. Thus it is debatable whether etanercept alone or combined with other drugs, is the treatment of choice for patients with tumour necrosis factor receptor-associated periodic syndrome. Conclusion:Since there is variability in treatment responses among different patients with tumour necrosis factor receptor-associated periodic syndrome, we suggest that a systematic evaluation of acute-phase reactants, especially SAA-1, could be useful in maintaining or modifying a given therapeutic approach in these patients.
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Abbreviations
- FMF :
-
familial Mediterranean fever
- HIDS :
-
hyper-IgD and periodic fever syndrome
- HPFS :
-
hereditary periodic fever syndromes
- MWS :
-
Muckle-Wells syndrome
- TNF α :
-
tumour necrosis factor α
- TNFR1 :
-
tumour necrosis factor receptor 1
- TRAPS :
-
tumour necrosis factor receptor-associated periodic syndrome
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Acknowledgements
We wish to thank the patient and his family for their participation, Dr L. Alvarez and Dr. M. Elena for technical assistance in the SAA-1 protein quantification, and Mike Maudsley for assistance in manuscript preparation. This study was supported by grant 003110 from the “MARATO TV3” sponsor.
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Both J. I. Aróstegui and P. Solís contributed equally to this work.
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Aróstegui, J.I., Solís, P., Aldea, A. et al. Etanercept plus colchicine treatment in a child with tumour necrosis factor receptor-associated periodic syndrome abolishes auto-inflammatory episodes without normalising the subclinical acute phase response. Eur J Pediatr 164, 13–16 (2005). https://doi.org/10.1007/s00431-004-1563-1
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DOI: https://doi.org/10.1007/s00431-004-1563-1