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Ankylosing spondylitis and other inflammatory spondyloarthritis increase the risk of developing type 2 diabetes in an Asian population

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Abstract

This study evaluated whether people with ankylosing spondylitis (AS) and spondyloarthritis are at higher risk of type 2 diabetes mellitus (T2DM). We used a sub-dataset of the National Health Insurance Research Database from 1996 to 2010 to established a AS cohort consisting new patients with AS or spondyloarthritis (N = 7,778) and a non-AS cohort without the diseases (N = 31,112). Incidences of T2DM in the two cohorts, hazard ratios (HRs) of risk of T2DM in association with AS, and cumulative probability of having T2DM were estimated by the end of 2010. The incidence of T2DM was 1.17-fold higher in the AS cohort than in the non-AS cohort (13.5 vs. 11.5, per 1,000 person-years), with an adjusted HR of 1.16 (95 % CI = 1.05–1.29). The T2DM incidence was higher for women than for men; while the Cox model measured sex-specific adjusted HR of T2DM was higher for men than for women. The incidence rate of T2DM increased with age in both cohorts, while the age-specific measures showed that the adjusted HR of T2DM was higher in young AS patients (≤50 years of age) than older ones, compared to their peers of non-AS group. The plot of Kaplan–Meier analysis showed that the overall probability of having T2DM was 2 % higher in the AS cohort than in the non-AS cohort (log-rank test: p < 0.0001). Patients with AS and spondyloarthritis have an increased risk of developing T2DM.

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Acknowledgments

The study was supported in part by the study projects (DMR-103-012) in our hospital and Taiwan Department of Health Clinical Trial and Research Center and for Excellence (DOH102-TD-B-111-004), and Taiwan Department of Health Cancer Research Center for Excellence (DOH102-TD-C-111-005).

Conflict of interest

All authors state that they have no conflicts of interest.

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Authors and Affiliations

  1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan

    Hsin-Hung Chen

  2. Division of Metabolism and Endocrinology, Changhua Christian Hospital, Changhua, Taiwan

    Hsin-Hung Chen

  3. Division of Metabolism and Endocrinology, Nantou Christian Hospital, Nantou, Taiwan

    Hsin-Hung Chen & Su-Yin Yeh

  4. Asia University, Taichung, Taiwan

    Su-Yin Yeh

  5. Department of Nuclear Medicine, E-DA Hospital, I-Shou University, Kaohsiung, Taiwan

    Hue-Yong Chen

  6. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan

    Cheng-Li Lin & Fung-Chang Sung

  7. Graduate Institute of Clinical Medicine Science and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung, 404, Taiwan

    Fung-Chang Sung & Chia-Hung Kao

  8. Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan

    Chia-Hung Kao

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  1. Hsin-Hung Chen
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  2. Su-Yin Yeh
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Correspondence to Chia-Hung Kao.

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Hue-Yong Chen and Hsin-Hung Chen have contributed equally to this manuscript.

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Chen, HH., Yeh, SY., Chen, HY. et al. Ankylosing spondylitis and other inflammatory spondyloarthritis increase the risk of developing type 2 diabetes in an Asian population. Rheumatol Int 34, 265–270 (2014). https://doi.org/10.1007/s00296-013-2927-5

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  • DOI: https://doi.org/10.1007/s00296-013-2927-5

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