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Relapsing polychondritis: a description of a case and review article

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Abstract

Relapsing polychondritis (RPC) is a rare autoimmune disease in which the cartilaginous tissues are the target for inflammation and destruction, the associated immune reaction causes inflammation in non-cartilaginous tissues like kidney and blood vessels. This article provides a description of a case of RPC and a review article about the disease.

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References

  1. Jaksch-Wartenhorst R (1923) Polychondropathia. Wien Arch F Inn Med 6:93–100

    Google Scholar 

  2. Pearson CM, Kline HM, Newcomer VD (1960) Relapsing polychondritis. N Engl J Med 263:51–58

    Article  PubMed  CAS  Google Scholar 

  3. Michet CJ (1997) Relapsing polychondritis in arthritis and allied condition: a text-book of rheumatology, 13th edn. In: Koopman WJ (ed). Willaims & Wilkins, pp 1593–1603

  4. Trentham DE, Le CH (1998) Relapsing polychondritis. Ann Intern Med 129(2):114–122

    PubMed  CAS  Google Scholar 

  5. Michet CJ Jr, McKenna CH, Luthra HS, O’Fallon WM (1986) Relapsing polychondritis: survival and predictive role of early disease manifestations. Ann Intern Med 104:74–78

    PubMed  Google Scholar 

  6. Letko E, Zafirakis P, Baltatzis S, Voudouri A, Livir-Rallatos C, Foster CS (2002) Relapsing polychondritis: a clinical review. Semin Arthritis Rheum 31(6):384–395

    Article  PubMed  Google Scholar 

  7. Lang B, Rothenfusser A, Lanchbury JS et al (1993) Susceptibility to relapsing polychondritis is associated with HLA-DR4. Arthritis Rheum 36(5):660–664

    Article  PubMed  CAS  Google Scholar 

  8. Zeuner M, Straub RH, Rauh G, Albert ED, Scholmerich J, Lang B (1997) Relapsing polychondritis: clinical and immunogenetic analysis of 62 patients. J Rheumatol 24(1):96–101

    PubMed  CAS  Google Scholar 

  9. Hue-Lemoine S, Caillat-Zucman S, Amoura Z et al (1999) HLA-DQA1, DQB1 alleles are associated with susceptibility to relapsing polychondritis: from transgenic mice to humans. Arthritis Rheum 42:S261

    Google Scholar 

  10. Foidart JM, Abe S, Martin GR et al (1978) Antibodies to type II collagen in relapsing polychondritis. N Engl J Med 299(22):1203–1207

    Article  PubMed  CAS  Google Scholar 

  11. Dolan DL, Lemmon GB Jr, Teitelbaum SL (1966) Relapsing polychondritis. Analytical literature review and studies on pathogenesis. Am J Med 41:285–299

    Article  PubMed  CAS  Google Scholar 

  12. Hansson AS, Heinegard D, Piette JC, Burkhardt H, Holmdahl R (2001) The occurrence of auto antibodies to matrilin 1 reflects a tissue-specific response to cartilage of the respiratory tract in patients with relapsing polychondritis. Arthritis Rheum 44(10):2402–2412

    Article  PubMed  CAS  Google Scholar 

  13. Rajapakse DA, Bywaters EG (1974) Cell-mediated immunity to cartilage proteoglycan in relapsing polychondritis. Clin Exp Immunol 16(3):497–502

    PubMed  CAS  Google Scholar 

  14. Ohwatari R, Fukuda S, Iwabuchi K, Inuyama Y, Onoé K (2001) Nishihira. Serum level of macrophage migration inhibitory factor as a useful parameter of clinical course in patients with Wegener’s granulomatosis and relapsing polychondritis. J Ann Otol Rhinol Laryngol 110(11):1035–1040

    CAS  Google Scholar 

  15. Stabler T, Piette JC, Chevalier X, Marini-Portugal A, Kraus VB (2004) Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation. Arthritis Rheum 50(11):3663–3667

    Article  PubMed  CAS  Google Scholar 

  16. Ebringer R, Rook G, Swana GT, Bottazzo GF, Doniach D (1981) Autoantibodies to cartilage and type II collagen in relapsing polychondritis and other rheumatic diseases. Ann Rheum Dis 40(5):473–479

    Article  PubMed  CAS  Google Scholar 

  17. McAdam LP, O’Hanlan MA, Bluestone R, Pearson CM (1976) Relapsing polychondritis: prospective study of 23 patients and a review of the literature. Medicine (Baltimore) 55(3):193–215

    Google Scholar 

  18. Michet CJ Jr, McKenna CH, Luthra HS, O’Fallon WM (1986) Relapsing polychondritis. Survival and predictive role of early disease manifestations. Ann Intern Med 104(1):74–78

    PubMed  Google Scholar 

  19. Cody DT, Sones DA (1971) Relapsing polychondritis: audio vestibular manifestations. Laryngoscope 81(8):1208–1222

    Article  PubMed  CAS  Google Scholar 

  20. Balsa A, Expinosa A, Cuesta M et al (1995) Joint symptoms in relapsing polychondritis. Clin Exp Rheumatol 13(4):425–430

    PubMed  CAS  Google Scholar 

  21. Isaak BL, Liesegang TJ, Michet CJ (1986) Ocular and systemic findings in relapsing polychondritis. Ophthalmology 93(5):681–689

    PubMed  CAS  Google Scholar 

  22. Kent PD, Michet CJ, Luthra HS (2004) Relapsing polychondritis. Curr Opin Rheumatol 16(1):56–61

    Article  PubMed  Google Scholar 

  23. Eng J, Sabanathan S (1991) Airway complications in relapsing polychondritis. Ann Thorac Surg 51(4):686–692

    Article  PubMed  CAS  Google Scholar 

  24. Ernst A, Rafaq S, Boisella P et al (2009) Relapsing polychondritis and airway involvement. Chest 135(4):1024–1030

    Article  PubMed  Google Scholar 

  25. Rafeq S, Trentham D, Ernst A (2010) Pulmonary manifestations of relapsing polychondritis. Clin Chest Med 31(3):513–518 Epub 2010 Jun 20

    Article  PubMed  Google Scholar 

  26. Lang-Lazdunski L, Hvass U, Paillole C et al (1995) Cardiac valve replacement in relapsing polychondritis. J Heart Valve Dis 4(3):227–235

    PubMed  CAS  Google Scholar 

  27. Cipriano PR, Alonso DR, Baltaxe HA et al (1976) Multiple aortic aneurysms in relapsing polychondritis. Am J Cardiol 37(7):1097–1102

    Article  PubMed  CAS  Google Scholar 

  28. Chang-Miller A, Okamura M, Torres VE et al (1987) Renal involvement in relapsing polychondritis. Medicine (Baltimore) 66(3):202–217

    CAS  Google Scholar 

  29. Dalal BI, Wallace AC, Slinger RP (1988) IgA nephropathy in relapsing polychondritis. Pathology (Phila) 20(1):85–89

    CAS  Google Scholar 

  30. Frances C, el Rassi R, Laporte JL, Rybojad M, Papo T, Piette JC (2001) Dermatologic manifestations of relapsing polychondritis. A study of 200 cases at a single center. Medicine (Baltimore) 80(3):173–179

    Article  CAS  Google Scholar 

  31. Levesque H, Kerleau JM, Ducrotte P et al (1990) Esophageal involvement in atrophic polychondritis. Presse Med 19(22):1056

    PubMed  CAS  Google Scholar 

  32. Sundaram MB, Rajput AH (1983) Nervous system complications of relapsing polychondritis. Neurology 33(4):513–515

    PubMed  CAS  Google Scholar 

  33. Hanslik T, Wechsler B, Piette J-C et al (1994) Central nervous system involvement in relapsing polychondritis. Clin Exp Rheumatol 12(5):539–541

    PubMed  CAS  Google Scholar 

  34. Lahmer T, Treiber M, von Werder A et al (2010) Relapsing polychondritis: an autoimmune disease with many faces. Autoimmun Rev 9(8):540–546

    Article  PubMed  CAS  Google Scholar 

  35. Piette JC, El-Rassi R, Amoura Z (1999) Antinuclear antibodies in relapsing polychondritis. Ann Rheum Dis 58(10):656–657

    Article  PubMed  CAS  Google Scholar 

  36. Balsa-Criado A, Gonzalez-Hernandez T, Cuesta MV et al (1990) Lupus anticoagulant in relapsing polychondritis. J Rheumatol 17:1426–1427

    PubMed  CAS  Google Scholar 

  37. Papo T, Piette JC, Le Thi Huong D et al (1993) Antineutrophil cytoplasmic antibodies in polychondritis. Ann Rheum Dis 52(5):384–385

    Article  PubMed  CAS  Google Scholar 

  38. Handrock K, Gross WL (1993) Relapsing polychondritis as a secondary phenomenon of primary systemic vasculitis. Ann Rheum Dis 52(12):895–897

    Article  PubMed  CAS  Google Scholar 

  39. Yang CL, Brinckmann J, Rui HF et al (1993) Autoantibodies to cartilage collagens in relapsing polychondritis. Arch Dermatol Res 285(5):245–249

    Article  PubMed  CAS  Google Scholar 

  40. Kempta Lekpa F, Piette JC, Bastuji-Garin S et al (2010) Serum cartilage oligomeric matrix protein (COMP) level is a marker of disease activity in relapsing polychondritis. Clin Exp Rheumatol 28(4):553–555 Epub 2010 Aug 30

    PubMed  CAS  Google Scholar 

  41. McDonald TJ, Devine KD, Weiland LH (1975) Nontraumatic, nonneoplastic subglottic stenosis. Ann Otol Rhinol Laryngol 84(6):757–763

    PubMed  Google Scholar 

  42. Cauhape P, Aumaitre O, Papo T et al (1993) A diagnostic dilemma: Wegener’s granulomatosis, relapsing polychondritis or both? Eur J Med 2(8):497–498

    PubMed  CAS  Google Scholar 

  43. Lipnick RN, Fink cw (1991) Acute airway obstruction in relapsing polychondritis: treatment with pulse methylprednisolone. J Rheumatol 18(1):98–99

    PubMed  CAS  Google Scholar 

  44. Damiani JM, Levine HL (1979) Relapsing polychondritis—report of ten cases. Laryngoscope 89(1):929–946

    PubMed  CAS  Google Scholar 

  45. Askari AD (1984) Colchicine for treatment of relapsing polychondritis. J Am Acad Dermatol 10(3):507–510

    Article  PubMed  CAS  Google Scholar 

  46. Martin J, Roenigk HH, Lynch W, Tingwald FR (1976) Relapsing polychondritis treated with dapsone. Arch Dermatol 112(9):1272–1274

    Article  PubMed  CAS  Google Scholar 

  47. Park J, Gowin KM, Schumacher HR Jr (1996) Steroid sparing effect of methotrexate in relapsing polychondritis. J Rheumatol 23(5):937–938

    PubMed  CAS  Google Scholar 

  48. Stewart KA, Mazenic DJ (1992) Pulse intravenous cyclophosphamide for kidney disease in relapsing polychondritis. J Rheumatol 19(3):498–500

    PubMed  CAS  Google Scholar 

  49. Goldenberg G, Sangueza OP, Jorizzo JL (2006) Successful treatment of relapsing polychondritis with mycophenolate mofetil. J Dermatolog Treat 17(3):158–159

    Article  PubMed  Google Scholar 

  50. Handler RP (2006) Leflunomide for relapsing polychondritis: successful long-term treatment. J Rheumatol 33(9):1916

    PubMed  Google Scholar 

  51. Irani BS, Martin-Hirsch DP, Clark D, Hand DW, Vize CE, Black J (1992) Relapsing polychondritis—a study of four cases. J Laryngol Otol 106(10):911–914

    Article  PubMed  CAS  Google Scholar 

  52. Terrier B, Aouba A, Bienvenu B et al (2008) Complete remission in refractory relapsing polychondritis with intravenous immunoglobulins. Clin Exp Rheumatol 26(1):136–138

    PubMed  CAS  Google Scholar 

  53. Leroux G, Costedoat-Chalumeau N, Brihaye B, Cohen-Bittan J, Amoura Z, Haroche J et al (2009) Treatment of relapsing polychondritis with rituximab: a retrospective study of nine patients. Arthritis Rheum 61(5):577–582

    Article  PubMed  CAS  Google Scholar 

  54. Ratzinger G, Kuen-Spiegl M, Sepp N (2009) Successful treatment of recalcitrant relapsing polychondritis with monoclonal antibodies. J Eur Acad Dermatol Venereol 23(4):474–475

    Article  PubMed  CAS  Google Scholar 

  55. Valesini G, Iannuccelli C, Marocchi E, Pascoli L, Scalzi V, Di Franco M (2007) Biological and clinical effects of anti-TNFα treatment. Autoimmun Rev 7(1):35–41

    Article  PubMed  CAS  Google Scholar 

  56. Lahmer T, Knopf A, Treiber M, Heemann U, Thuermel K (2010) Treatment of relapsing polychondritis with the TNF-alpha antagonist adalimumab. Clin Rheumatol. [Epub ahead of print]

  57. Adliff M, Ngato D, Keshavjee S, Brenaman S, Granton JT (1997) Treatment of diffuse tracheomalacia secondary to relapsing polychondritis with continuous positive airway pressure. Chest 112(6):1701–1704

    Article  PubMed  CAS  Google Scholar 

  58. Sarodia BD, Dasguta A, Mehta AC (1999) Management of airway complications of relapsing polychondritis. Case reports and review of the literature. Chest 116(6):1669–1675

    Article  PubMed  CAS  Google Scholar 

  59. Del Rosso A, Petix NR, Pratesi M, Bini A (1997) Cardiovascular involvement in relapsing polychondritis. Semin Arthritis Rheum 26(6):840–844

    Article  PubMed  CAS  Google Scholar 

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Edrees, A. Relapsing polychondritis: a description of a case and review article. Rheumatol Int 31, 707–713 (2011). https://doi.org/10.1007/s00296-010-1775-9

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