Abstract
This retrospective study analyzed the HLA-B*27 alleles in a group of 20 consecutive patients with the diagnosis of Reiter syndrome (RS) followed in a tertiary referral university hospital in Brazil, during the period 1990–2006, and compared the data with that observed in other patients with spondyloarthropathies followed at the same institution. Eight cases were associated to gastrointestinal infection, eight cases to previous urethritis, and four cases presented no established preceding infection. HLA-B*27 alleles were typed by polymerase chain reaction-amplified DNA hybridized with sequence-specific oligonucleotide probes (HLA-B*2701 to HLA-B*2721). They were compared to a group of 108 patients with ankylosing spondylitis (AS), 40 with undifferentiated spondyloarthropathy (uSpA) and 111 healthy controls. Among the 20 patients, 17 were HLA-B*27 positive (85%). Two HLA-B*27 alleles were observed: HLA-B*2705 (65%) and HLA-B*2702 (35%). In the other spondyloarthropathies, the observed alleles were HLA-B*2705 (90% in AS and 92.5% in uSpA), HLA-B*2702 (8% in AS and 5% in uSpA), HLA-B*2704 (1% in AS and 2.5% in uSpA) and HLA-B*2713 (1% in AS). Among the 111 healthy controls, 80% presented HLA-B*2705, followed by HLA-B*2702 in 10%, HLA-B*2703 in 6%, HLA-B*2707 in 3% and HLA-B*2713 in 1%. Concluding, in the HLA-B*27 positive patients with RS in this study there was predominance of HLA-B*2705 allele, in a lower frequency than that observed in patients with other spondyloarthropathies and healthy controls.
References
Reiter H (1916) Uber eine bisher unerkannte Spirochäten infection. DMW 42:1535–1536
Fiessinger N, Leroy E (1916) Contribution à l´étude d´une épidémie de dysenterie dans la Somme. Bull Mem Soc Med Hop Paris 40:2030–2069
Moll JMH, Haslock I, Macrae IF et al (1974) Association between spondylitis, psoriatic arthritis, Reiter’s disease, the intestinal arthropathies and Behcet’s syndrome. Medicine (Baltimore) 53:343–364
Aho K, Ahvonen P, Lassus A et al (1974) HLA B27 in reactive arthritis. A study of Yersinia arthritis and Reiter’s disease. Arthritis Rheum 17:521–526
Michet CJ, Machado EBV, Ballard DJ, McKenna CH (1988) Epidemiology of Reiter’s syndrome in Rochester, Minnesota 1950–1980. Arthritis Rheum 31:428–432
Thomson GTD, De Rubeis DA, Hodge MA et al (1995) Post-Salmonella reactive arthritis: late clinical sequelae in a point source cohort. Am J Med 98:13–21
Iliopoulos A, Karras D, Ioakimidis D et al (1995) Change in the epidemiology of Reiter’s syndrome (reactive arthritis) in the post-AIDS era? An analysis of cases appearing in the Greek army. J Rheumatol 22:252–254
Leirisalo M, Skylv G, Kousa M et al (1982) Followup study of patients with Reiter’s disease and reactive arthritis, with special reference to HLA-B27. Arthritis Rheum 25:249–259
Arnett FC, Hochberg MC, Bias WB (1977) Cross-reactive HLA antigens in B27-negative Reiter’s syndrome and sacroiliitis. Johns Hopkins Med J 141:193–197
Ben-Chetrit E, Brautbar C, Rubinow A (1985) HLA antigens in Reiter’s syndrome in Israeli patients. J Rheumatol 12:964–966
Stein M, Davis P, Emmanuel J, West G (1990) The spondyloarthropathies in Zimbabwe: a clinical and immunologic profile. J Rheumatol 17:1337–1339
Keat A (1983) Reiter’s syndrome and reactive arthritis in perspective. N Engl J Med 309:1606–1615
Cuttica RJ, Scheines EJ, Garay SM, Romanelli MDC, Maldonado-Cocco JA (1992) Juvenile onset Reiter’s syndrome. A retrospective study of 26 patients. Clin Exp Rheumatol 10:285–288
Butler M, Russell AS, Percy JS, Lentle BC (1979) A follow-up study of 48 patients with Reiter’s syndrome. Am J Med 67:868–870
Sampaio-Barros PD, Conde RA, Donadi EA et al (2003) Undifferentiated spondyloarthropathies in Brazilians: importance of HLA-B27 and the B7-CREG alleles in characterization and disease progression. J Rheumatol 30:2632–2637
Sampaio-Barros PD, Bertolo MB, Kraemer MHS, Marques Neto JF, Samara AM (2001) Primary ankylosing spondylitis: patterns of disease in a Brazilian population of 147 patients. J Rheumatol 28:560–565
Conde RA, Sampaio-Barros PD, Donadi EA et al (2003) Frequency of the HLA-B27 alleles in Brazilian patients with ankylosing spondylitis. J Rheumatol 30:2511–2512
Reveille JD, Ball EJ, Khan MA (2001) HLA-B27 and genetic predisposing factors in spondyloarthropathies. Curr Opin Rheumatol 13:265–272
Sampaio-Barros PD, Conde RA, Bonfiglioli R, Bertolo MB, Samara AM (2006) Characterization and outcome of uveitis in 350 patients with spondyloarthropathies. Rheumatol Int 26:1143–1146
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This work was supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP).
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Sampaio-Barros, P.D., Conde, R.A., Donadi, E.A. et al. Frequency of HLA-B27 and its alleles in patients with Reiter syndrome: comparison with the frequency in other spondyloarthropathies and a healthy control population. Rheumatol Int 28, 483–486 (2008). https://doi.org/10.1007/s00296-007-0441-3
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DOI: https://doi.org/10.1007/s00296-007-0441-3