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Association of Crohn's disease and Cogan's syndrome

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Summary

We describe the case of a young woman with Cogan's syndrome and associated Crohn's disease. Systemic disease was manifested by oligoarthritis and valvular involvement. Crohn's disease has previously been described in two cases of Cogan's syndrome. We suggest therefore that Crohn's disease is pathogenetically related to Cogan's syndrome. For both, systemic involvement is characteristic, and immune-mediated mechanisms and vasculitis are thought to play a major pathogenetic role. Furthermore, both respond to treatment with corticosteroids.

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References

  1. Cogan DG: Syndrome of nonsyphilitic interstitial keratitis and vestibuloauditory symptoms. Arch Ophthalmol 33:144–149, 1945

    Google Scholar 

  2. Thomas HG: Case report: Clinical and radiological features of Cogan's syndrome—non-syphilitic interstitial keratitis, audiovestibular symptoms and systemic manifestations. Clin Radiol 45:418–421, 1992

    PubMed  Google Scholar 

  3. Ferrari E, Taillan B, Garnier G, Dor V, Morand P, Dujardin P: Manifestations cardiovasculaires du syndrome de Cogan. Arch Mal Coeur 85:913–916, 1992

    PubMed  Google Scholar 

  4. La Raja RD: Cogan syndrome associated with mesenteric vascular insufficiency. Arch Surg 111:1028–1031, 1976

    PubMed  Google Scholar 

  5. Buge A, Chamouard JM, Michon C, Schadeck B, Baglin G, Vincent D, Blétry O, Godeau P: Syndrome de Cogan: À propos d'un cas. Association avec une maladie de Crohn. Ann Med Interne 137:75–78, 1986 (letter)

    Google Scholar 

  6. Fair JR, Levi GA: Keratitis and deafness. Am J Ophthalmol 49:1017–1021, 1960

    PubMed  Google Scholar 

  7. Haynes BF, Kaiser-Kupfer MI, Mason P, Fauci AS: Cogan syndrome studies in thirteen patients, long-term follow-up and a review of the literature. Medicine 59:426–441, 1980

    PubMed  Google Scholar 

  8. Hughes GB, Kinney SE, Parna BP, Tomsak RL, Calabrese LH: Autoimmune reactivity in Cogan's syndrome: A preliminary report. Otolaryngol Head Neck Surg 91:24–32, 1983

    PubMed  Google Scholar 

  9. Vinceneux PH, Pouchot J: Syndrome de Cogan.In Les maladies systémiques. MF Kahn, AP Pellier, O Meyer, JC Piette (eds). Paris, Médecine-Sciences, Flammarion, 1991, pp 753–762

    Google Scholar 

  10. Landi B, N'Guyen Anh T, Cortot A, Soule JC, Rene E, Gendre JP, Bories P, See A, Metman EH, Florent C, Lerebours E, Mary JY, Modigliani R: Endoscopic monitoring of Crohn's disease treatment: A prospective, randomized clinical trial. Gastroenterology 102:1647–1653, 1992

    PubMed  Google Scholar 

  11. Oliner L, Taubenhaus M, Shapira T, Leshin N: Nonsyphilitic interstitial keratitis and bilateral deafness (Cogan's syndrome) associated with essential polyangitis (periarteritis nodosa). N Engl J Med 248:1001–1008, 1953

    PubMed  Google Scholar 

  12. Crawford WJ: Cogan's syndrome associated with polyarteritis nodosa: A report of three cases. Pa Med J 60:835–838, 1957

    PubMed  Google Scholar 

  13. Fisher ER, Hellstrom HR: Cogan's syndrome and systemic vascular disease. Arch Pathol 72:96–116, 1961

    Google Scholar 

  14. Cheson BD, Bluming AZ, Alroy J: Cogan's syndrome: A systemic vasculitis. Am J Med 60:549–555, 1976

    PubMed  Google Scholar 

  15. Vollertsen RS, McDonald TJ, Younge BR, Banks PM, Stanson AW, Ilstrup DM: Cogan's syndrome: 18 cases and a review of the literature. Mayo Clin Proc 61:344–361, 1986

    PubMed  Google Scholar 

  16. Knox RL, Schachat AP, Mustonsen E: Primary secondary and coincidental ocular complications of Crohn's disease. Ophthalmology 91:163–173, 1984

    PubMed  Google Scholar 

  17. Mayer L, Janowitz H: Extraintestinal manifestations of inflammatory bowel disease.In Inflammatory Bowel Disease. JB Kirsner, RG Shorter (eds). New York, Lea and Febiger, 1988, pp 299–317

    Google Scholar 

  18. Yassinger S: Association of inflammatory bowel disease and large vascular lesions. Gastroenterology 71:844A, 1979

    Google Scholar 

  19. Geller SA, Cohen A: Arterial inflammatory cell-infiltration in Crohn's disease. Arch Pathol Lab Med 107:473, 1983

    PubMed  Google Scholar 

  20. Wakefield AJ, Sawyerr AM, Dhillon AP, Pitillo RM, Rowles PM, Lewis AAM, Pounder RE: The pathogenesis of Crohn's disease: Multifocal gastrointestinal infarction. Lancet 2:1057–1062, 1989

    PubMed  Google Scholar 

  21. Wakefield AJ, Dhillon AP, Sawyerr AM, Sankey EA, More L, Sim R, Pittilo RM, Rowles OM, Hudson M, Lewis AAM, Pounder RE: Granulomatous vasculitis in Crohn's disease. Gastroenterology 100:1279–1287, 1991

    PubMed  Google Scholar 

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Froehlich, F., Fried, M., Gonvers, J.J. et al. Association of Crohn's disease and Cogan's syndrome. Digest Dis Sci 39, 1134–1137 (1994). https://doi.org/10.1007/BF02087569

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  • DOI: https://doi.org/10.1007/BF02087569

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