Summary
Twenty male hyperuricaemic patients with normal kidney function were studied and it was found that the serum concentrations and excretions rates in the 24-hour urine of allopurinol and oxipurinol do not differ significantly after 9 days of oral treatment with either 300 mg allopurinol or a combination of 300 mg allopurinol and 60 mg benzbromarone daily. The sum of the excretion rates of the two pyrazolopyrimidines in the 24-hour urine represents 80.9% and 77.1%, respectively, of the daily dose of ailopurinol given alone or in combination with benzbromarone. As expected, the hypouricaemic effect of the combined therapy turned out to be stronger than that observed after monotherapy with allopurinol, due to the uricosuric component of benzbromarone. The difference was found to be highly significant.
This is a preview of subscription content, log in via an institution to check access.
References
Arntz HR, Dreykluft HR, Leonhardt H (1979) Wirkung harnsäuresenkender Medikamente in niedriger Dosierung bei Patienten mit Hyperurikämie und Hypertriglyzeridämie im randomisierten Blockversuch. Fortschr Med 97:1212–1214
Breithaupt H, Tittel M (1982) Kinetics of allopurinol after single intravenous and oral doses. Noninteraction with benzbromarone and hydrochlorothiazide. Eur J Clin Pharmacol 22:77–84
Elion GE, Yü TF, Gutman AB, Hitchings GH (1968) Renal clearance of oxipurinol, the chief metabolite of allopurinol. Am J Med 45:69–77
Kramer WG, Feldman S (1979) High performance chromatographic assay of allopurinol and oxipurinol in human plasma. J Chromatogr 162:94–97
Löffler W, Simmonds HA, Gröbner W (1983) Gout and uric acid nephropathy: Some new aspects in diagnosis and treatment. Klin Wochenschr 61:1233–1239
Matzkies F, Berg G (1976) Behandlung der Hyperurikämie mit einer Kombination von Allopurinol und Benzbromaron. Dtsch Med Wochenschr 101:1568–1570
Mertz DP (1976) Vermindertes Risiko bei Behandlung von Gicht und Hyperurikämie. Dtsch Med Wochenschr 101:1288–1292
Mertz DP, Borner K (1983) Ausscheidung und Serumkonzentrationen von Allopurinol, Oxipurinol und Oxipurinen unter kombinierter Behandlung mit Allopurinol/Benzbromaron in steigender Dosierung. Med Welt 34:974–979
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mertz, D.P., Eichhorn, R. Does benzbromarone in therapeutic doses raise renal excretion of oxipurinol?. Klin Wochenschr 62, 1170–1172 (1984). https://doi.org/10.1007/BF01712184
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01712184