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Advances in Minimally Invasive Surgery and Therapy for Spine and Nerves pp 49–53Cite as

Modic Changes: Anatomy, Pathophysiology and Clinical Correlation

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Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 108))

Abstract

Studying discovertebral complex anatomy is extremely important for the understanding of the pathophysiology of disc degeneration which leads to vertebral endplates signal changes, also known as Modic changes.

The sequelae of disc degeneration are among the leading causes of functional incapacity in both sexes and are one of the most common sources of chronic disability in the working years. Even if the presence of degenerative changes in MRI of the spine is by no means an indicator of symptoms, we are concordant in a positive association between Modic changes and low back pain, above all as a relatively specific but insensitive sign of discogenic low back pain.

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Conflict of interest statementWe declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Radiology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy

    C. C. Quattrocchi, A. M. Alexandre & B. B. Zobel

  2. Department of Neurosurgery, Catholic University of Rome, Via Longoni, 47, 00155, Rome, Italy

    G. M. Della Pepa

  3. Department of Neurology, University Campus Bio-Medico of Rome, via Longoni, 47, 00155, Rome, Italy

    R. Altavilla

Authors
  1. C. C. Quattrocchi
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  2. A. M. Alexandre
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  3. G. M. Della Pepa
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  4. R. Altavilla
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  5. B. B. Zobel
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Corresponding author

Correspondence to C. C. Quattrocchi .

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Editors and Affiliations

  1. Istituto per lo studio e la cura delle, mallettie del sistema nervoso perif., European Neurosurgical Institut, Via Ghirada 2, Treviso, 31100, Italy

    Alberto Alexandre

  2. University of Planalto Central and South, School of Medicine, SCN Qd 05 Bl. A Sala 912, Brazil, Brazil

    Marcos Masini

  3. Florence and Rome University, Via Jacopo Nardi 15, Florence, 50132, Italy

    Pier Paolo Maria Menchetti

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Quattrocchi, C.C., Alexandre, A.M., Pepa, G.M.D., Altavilla, R., Zobel, B.B. (2011). Modic Changes: Anatomy, Pathophysiology and Clinical Correlation. In: Alexandre, A., Masini, M., Menchetti, P. (eds) Advances in Minimally Invasive Surgery and Therapy for Spine and Nerves. Acta Neurochirurgica Supplementum, vol 108. Springer, Vienna. https://doi.org/10.1007/978-3-211-99370-5_9

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  • DOI: https://doi.org/10.1007/978-3-211-99370-5_9

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  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-99369-9

  • Online ISBN: 978-3-211-99370-5

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