Regular ArticlesPATHWAYS BY WHICH INTERLEUKIN 17 INDUCES ARTICULAR CARTILAGE BREAKDOWN IN VITRO AND IN VIVO
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2013, CytokineCitation Excerpt :In the same study, IL-17 was shown to induce the expression of MMP-1, MMP-3 and MMP-13 in bovine chondrocytes [99]. Furthermore, IL-17 was able to stimulate aggrecanase activity in bovine and porcine cartilage during the breakdown [100]. The induction of MMP-3, MMP-13 and aggrecanase-1 expression is dependent on the phosphorylation of mitogen-activated protein kinases: ERK, p38 and JNK proteins; AP-1 and NF-κB transcription factors [101].
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Correspondence to: Dr Ellen H. Filvaroff, Department of Molecular Oncology, Genentech Inc., MS 37, 1 DNA Way, South San Francisco, CA 94080-4990, USA. Tel: 650-225-1159; Fax: 650-225-6497; E-mail:[email protected]
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