Total group and U3RNP+ group, SSc pattern, capillary loss, and organ involvement.
| Cardiac Involvement (negative) | Cardiac Involvement (positive) | Pulmonary Involvement (negative) | Pulmonary Involvement (positive) | |
|---|---|---|---|---|
| All | n = 37 | n = 8 | n = 42 | n = 3 |
| Early, n = 9 | 8 (22) | 1 (13) | 9 (21) | 0 (0) |
| Active, n = 20 | 18 (47) | 2 (26) | 20 (58) | 0 (0) |
| Late, n = 10 | 6 (17) | 4 (52) | 7 (17) | 3 (100)* |
| Secondary, n = 6 | 5 (14) | 1 (13) | 6 (14) | 0 (0) |
| U3RNP+ | n = 13 | n = 2 | n = 15 | n = 0 |
| Early, n = 1 | 1 (8) | 0 (0) | 1 (6) | 0 (0) |
| Active, n = 6 | 6 (46) | 0 (0) | 6 (40) | 0 (0) |
| Late, n = 4 | 3 (23) | 1 (50) | 4 (27) | 0 (0) |
| Secondary, n = 4 | 3 (23) | 1 (50) | 4 (27) | 0 (0) |
| All | n = 37 | n = 8 | n = 42 | n = 3 |
| Capillary loss (−), n = 26 | 24 (65) | 2 (25) | 26 (62) | 0 (0) |
| Capillary loss (+), n = 19 | 13 (35) | 6 (75)** | 16 (38) | 3 (100) |
| U3RNP+ | n = 13 | n = 2 | n = 15 | n = 0 |
| Capillary loss (−), n = 8 | 8 (61) | 0 (0) | 8 (53) | 0 (0) |
| Capillary loss (+), n = 7 | 5 (39) | 2 (100) | 7 (47) | 0 (0) |
Values are n (%) unless otherwise specified.
↵* P value = 0.009 chi square; late pattern vs non late pattern.
↵** P value = 0.047 chi square; capillary loss vs no loss, all other comparisons nonsignificant. Cardiac involvement defined as a Medsger score of 1 or higher, or at least 2 of the following: decreased LVEF, arrhythmias, conduction abnormalities, diastolic dysfunction, or pericardial effusion. Pulmonary involvement defined as decreased FVC and DLCO and ILD on HRCT. SSc: systemic sclerosis; LVEF: left ventricular ejection fraction; FVC: forced vital capacity; ILD: interstitial lung disease; HRCT: high-resolution computed tomography.