Standardized response means of combined scores, individual MRI pathologies, radiographic (CR), and clinical variables (95% CI).
| Measures | Derivation Cohort | Validation Cohort |
|---|---|---|
| Inflammatory measures | ||
| 1. Unweighted summation | 0.78 (0.70–0.85) | 0.62 (0.51–0.73) |
| 2. Normalized summation | 0.82 (0.74–0.90) | 0.73 (0.63–0.83) |
| 3. Weighted summation | 0.84 (0.76–0.92) | 0.74 (0.64–0.84) |
| 4. Adjusted-weighted summation | 0.84 (0.76–0.92) | 0.74 (0.65–0.84) |
| 5. Single site–weighted summation | 1.10 (0.99–1.21) | 0.60 (0.50–0.70) |
| RAMRIS synovitis | 0.74 (0.65–0.83) | 0.65 (0.54–0.76) |
| RAMRIS tenosynovitis | 0.81 (0.73–0.89) | 0.76 (0.66–0.86) |
| RAMRIS bone marrow edema | 0.36 (0.29–0.42) | 0.13 (0.02–0.24) |
| Damage measures | ||
| 1. Unweighted summation | 0.35 (0.21–0.49) | 0.43 (0.35–0.52) |
| 2. Normalized summation | 0.29 (0.14–0.43) | 0.44 (0.38–0.50) |
| 3. Weighted summation | 0.43 (0.31–0.55) | 0.40 (0.30–0.51) |
| 4. Adjusted-weighted summation | 0.38 (0.25–0.51) | 0.46 (0.36–0.56) |
| 5. Single site–weighted summation | 0.58 (0.44–0.71) | 0.41 (0.34–0.48) |
| RAMRIS erosion | 0.35 (0.26–0.45) | 0.36 (0.27–0.45) |
| RAMRIS JSN | 0.23 (0.10–0.35) | 0.35 (0.30–0.40) |
| CR erosion | 0.52 (0.44–0.59) | 0.19 (0.10–0.28) |
| CR JSN | 0.35 (0.30–0.40) | 0.20 (0.14–0.26) |
| CR total | 0.55 (0.48–0.61) | 0.26 (0.19–0.34) |
MRI: magnetic resonance imaging; CR: conventional radiography [CR scored by modified Sharp/van der Heijde score (hands, wrists, and feet)]; JSN: joint space narrowing; RAMRIS: Outcome Measures in Rheumatology rheumatoid arthritis MRI scoring system.