Demographic and clinical characteristics of patients with RA-ILD from 2004 to 2013.
| Year | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 2004, n = 648 | 2005, n = 676 | 2006, n = 738 | 2007, n = 857 | 2008, n = 1085 | 2009, n = 1346 | 2010, n = 1549 | 2011, n = 1775 | 2012, n = 1596 | 2013, n = 1575 | |
| Demographics | ||||||||||
| Mean age, yrs | 65.7 ± 11.8 | 65.2 ± 12.0 | 64.7 ± 12.2 | 64.7 ± 12.5 | 63.9 ± 12.3 | 64.5 ± 12.3 | 65.2 ± 12.4 | 64.6 ± 12.4 | 65.5 ± 12.6 | 65.1 ± 12.8 |
| Female | 434 (67.0) | 446 (66.0) | 512 (69.4) | 588 (68.6) | 739 (68.1) | 923 (68.6) | 1078 (69.6) | 1235 (69.6) | 1119 (70.1) | 1096 (69.6) |
| Clinical characteristics | ||||||||||
| Mean RA severity scorea | 4.0 ± 1.5 | 4.0 ± 1.5 | 4.1 ± 1.5 | 4.3 ± 1.6 | 4.4 ± 1.6 | 4.4 ± 1.6 | 4.3 ± 1.6 | 4.3 ± 1.6 | 4.2 ± 1.6 | 4.3 ± 1.6 |
| Comorbidities | ||||||||||
| PH | 30 (4.6) | 42 (6.2) | 46 (6.2) | 65 (7.6) | 68 (6.3) | 92 (6.8) | 121 (7.8) | 140 (7.9) | 109 (6.8) | 95 (6.0) |
| CAD | 167 (25.8) | 160 (23.7) | 157 (21.3) | 199 (23.2) | 262 (24.1) | 340 (25.3) | 381 (24.6) | 439 (24.7) | 391 (24.5) | 387 (24.6) |
| Hypertension | 277 (42.7) | 288 (42.6) | 337 (45.7) | 351 (41.0) | 538 (49.6) | 755 (56.1) | 855 (55.2) | 1037 (58.4) | 956 (59.9) | 961 (61.0) |
| Obesity | 9 (1.4) | 9 (1.3) | 11 (1.5) | 14 (1.6) | 40 (3.7) | 75 (5.6) | 103 (6.6) | 122 (6.9) | 131 (8.2) | 158 (10.0) |
| Sleep apnea | 0 (0) | 17 (2.5) | 37 (5.0) | 75 (8.8) | 129 (11.9) | 180 (13.4) | 234 (15.1) | 294 (16.6) | 246 (15.4) | 262 (16.6) |
| GERD | 299 (46.1) | 356 (52.7) | 375 (50.8) | 442 (51.6) | 587 (54.1) | 727 (54.0) | 759 (49.0) | 948 (53.4) | 820 (51.4) | 822 (52.2) |
| Dyslipidemia | 225 (34.7) | 237 (35.1) | 256 (34.7) | 344 (40.1) | 476 (43.9) | 651 (48.4) | 759 (49.0) | 902 (50.8) | 820 (51.4) | 825 (52.4) |
| Diabetes | 138 (21.3) | 152 (22.5) | 155 (21.0) | 189 (22.1) | 258 (23.8) | 337 (25.0) | 390 (25.2) | 466 (26.3) | 395 (24.7) | 382 (24.3) |
| Emphysema | 32 (4.9) | 40 (5.9) | 39 (5.3) | 37 (4.3) | 55 (5.1) | 94 (7.0) | 105 (6.8) | 110 (6.2) | 115 (7.2) | 104 (6.6) |
| Chronic bronchitis | 98 (15.1) | 123 (18.2) | 114 (15.4) | 127 (14.8) | 174 (16.0) | 254 (18.9) | 259 (16.7) | 297 (16.7) | 249 (15.6) | 234 (14.9) |
| Acute bronchitis/pneumonia | 226 (34.9) | 244 (36.1) | 248 (33.6) | 297 (34.7) | 364 (33.5) | 517 (38.4) | 587 (37.9) | 634 (35.7) | 574 (36.0) | 592 (37.6) |
| Tobacco use disorder | 10 (1.5) | 12 (1.8) | 22 (3.0) | 38 (4.4) | 44 (4.1) | 93 (6.9) | 94 (6.1) | 134 (7.5) | 99 (6.2) | 129 (8.2) |
| Medications | ||||||||||
| Use of glucocorticoids (oral or intravenous) | 529 (81.6) | 560 (82.8) | 599 (81.2) | 684 (79.8) | 866 (79.8) | 1085 (80.6) | 1252 (80.8) | 1438 (81.0) | 1288 (80.7) | 1281 (81.3) |
| Use of azathioprine | 93 (14.4) | 90 (13.3) | 104 (14.1) | 127 (14.8) | 165 (15.2) | 202 (15.0) | 223 (14.4) | 238 (13.4) | 203 (12.7) | 208 (13.2) |
| Use of supplemental oxygen | 237 (36.6) | 245 (36.2) | 285 (38.6) | 299 (34.9) | 416 (38.3) | 503 (37.4) | 629 (40.6) | 713 (40.2) | 612 (38.3) | 593 (37.7) |
| Procedures | ||||||||||
| Chest CT scan | 378 (58.3) | 400 (59.2) | 421 (57.0) | 496 (57.9) | 626 (57.7) | 733 (54.5) | 785 (50.7) | 917 (51.7) | 799 (50.1) | 792 (50.3) |
| Chest radiograph | 519 (80.1) | 519 (76.8) | 565 (76.6) | 629 (73.4) | 775 (71.4) | 990 (73.6) | 1120 (72.3) | 1321 (74.4) | 1122 (70.3) | 1084 (68.8) |
| Lung biopsy | 80 (12.3) | 86 (12.7) | 77 (10.4) | 100 (11.7) | 113 (10.4) | 128 (9.5) | 140 (9.0) | 139 (7.8) | 110 (6.9) | 148 (9.4) |
Data are presented as mean ± SD or n (%).
↵a Measured using the CIRAS algorithm. CAD: coronary artery disease; GERD: gastroesophageal reflux disease; RA-ILD: rheumatoid arthritis–related interstitial lung disease; PH: pulmonary hypertension; CT: computed tomography; CIRAS: Claims-based Index for RA Severity.