Characteristics of adults who develop accelerated HOA with no joints with advance-stage disease (Kellgren-Lawrence grade 3 or 4) at baseline. Values are n (%) unless otherwise specified.
| Variables | No Accelerated HOA, n = 2741 | Accelerated HOA, n = 21 | Difference Between Groups (95% CI) |
|---|---|---|---|
| Baseline characteristics* | |||
| Female | 1495 (55) | 16 (76) | 22 (3–40)a |
| Premenopause | 290 (20) | 2 (13) | −7 (−2.3 to 9) |
| Perimenopause | 250 (17) | 1 (6) | −11 (−23 to 1) |
| Postmenopause | 947 (64) | 13 (81) | 18 (−2 to 37)a |
| Metabolic syndrome, 2–4 components | 1369 (54) | 10 (50) | −4 (−26 to 18) |
| Self-reported diabetes | 177 (7) | 1 (5) | −2 (−11 to 8) |
| Use of lipid medications | 690 (26) | 4 (20) | −6 (−24 to 12) |
| High blood pressure | 1492 (56) | 13 (65) | 9 (−12 to 30) |
| Large waist circumference | 1877 (73) | 13 (65) | −8 (−29 to 13) |
| Physician-diagnosed HOA | 285 (10) | 5 (24) | 13 (−5 to 32)a |
| Prevalent hand pain | 470 (17) | 9 (43) | 26 (5–47)a |
| Age, yrs, mean (SD) | 59.1 (8.6) | 62.4 (8.0) | 3.3 (0.43–7.0) |
| Body mass index, kg/m2, mean (SD) | 28.6 (4.9) | 27.4 (4.8) | −1.2 (−3.3 to 0.9) |
| Body weight, kg, mean (SD) | 82.3 (16.5) | 75.3 (14.2) | −7.0 (−12.1 to −1.7) |
| Baseline radiographic hand characteristics* | |||
| Radiographic HOA | 629 (23) | 12 (57) | 34 (13–55) |
| Central erosions, ≥ 1 joint | 5 (< 1) | 0 (0) | −0.1 (0.0–0.3) |
| Marginal erosions, ≥ 1 joint | 51 (2) | 1 (5) | 3 (−6 to 13)a |
| Incident findings over time | |||
| Incident accelerated knee OA | 78 (3) | 1 (5) | 2 (−7 to 11) |
| New central erosions over 48 mos | 24 (< 1) | 6 (30) | 29 (9–49) |
| New marginal erosions over 48 mos | 28 (1) | 1 (5) | 4 (−6 to 14) |
↵* Collected at baseline.
↵a Discordance in group difference is related to rounding. Notes on missing data: Only included people with body weight, and status of self-reported hand pain (yes or no), and physician-diagnosed HOA (yes and no or unknown) at baseline. Missing data: Less than 3% missing data for menopause status, central erosions, marginal erosions, diabetes status, and waist circumference. Metabolic syndrome (n missing = 137 controls). No other missing data. HOA: hand osteoarthritis.