Association of NOTCH4 variants with SSc by allelic model in the US cohort.
| SNP | Change | MAF (case/control) | p | OR (95% CI) | P Corrected |
|---|---|---|---|---|---|
| rs1044507 | C/A | 0.014/0.031 | 3.81 × 10−6 | 0.38 (0.24–0.62) | 4.57 × 10−5 |
| rs204987 | T/C | 0.042/0.063 | 1.1 × 10−7 | 0.37 (0.24–0.56) | 1.32 × 10−6 |
| rs415929 | C/T | 0.016/0.042 | 1.57 × 10−6 | 1.34 (1.17–1.54) | 1.89 × 10−5 |
| rs422951 | C/T | 0.326/0.278 | 4.02 × 10−4 | 1.21 (1.06–1.38) | 4.82 × 10−3 |
| rs423023 | C/G | 0.460/0.412 | 8.81 × 10−5 | 1.27 (1.10–1.46) | 1.06 × 10−3 |
| rs443198 | G/A | 0.344/0.284 | 1.26 × 10−5 | 0.77 (0.67–0.88 | 1.51 × 10−4 |
| rs520688 | C/T | 0.344/0.284 | 5.44 × 10−6 | 1.32 (1.15–1.51) | 6.53 × 10−5 |
| rs520692 | C/T | 0.344/0.284 | 5.44 × 10−6 | 1.32 (1.15–1.51) | 6.53 × 10−5 |
| rs520803 | T/C | 0.344/0.285 | 5.44 × 10−6 | 1.32 (1.15–1.51) | 6.53 × 10−5 |
| rs8192579 | C/T | 0.319/0.362 | 3.75 × 10−4 | 0.65 (0.49–0.88) | 4.5 × 10−3 |
| rs915894 | G/T | 0.313/0.370 | 2.25 × 10−4 | 0.81 (0.71–0.93) | 2.7 × 10−3 |
| (CTG)n | 10CTG | 0.411/0.401 | — | 1.00 | — |
| 12CTG | 0.111/0.105 | 0.78 | 1.04 (0.84–1.28) | 1.000 | |
| 11CTG | 0.129/0.093 | 5.97 × 10−3 | 1.35 (1.09–1.67) | 0.036 | |
| 13CTG | 0.011/0.029 | 4.97 × 10−5 | 0.35 (0.21–0.59) | 2.98 × 10−4 | |
| 9CTG | 0.203/0.271 | 1.66 × 10−4 | 0.73 (0.62–0.86) | 9.95 × 10−4 | |
| 6CTG | 0.132/0.099 | 0.015 | 1.3 (1.06–1.6) | 0.093 | |
| 5CTG | 0.004/0.003 | 0.83 | 1.3 (0.45–3.77) | 1.000 |
SSc: systemic sclerosis; SNP: single-nucleotide polymorphism; MAF: minor allele frequency.