Association of variants with autoantibody subtypes of SSc in the US cohort.
A. Association without conditioning on SSc-associated HLA genotypes.
| ACA+ vs Control | ATA+ vs Control | ARA+ vs Control | ||||
|---|---|---|---|---|---|---|
| SNP | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p |
| rs443198 | 0.54 (0.42–0.69) | 1.6 × 10−6 | 0.57 (0.42–0.77) | 2.4 × 10−4 | 0.77 (0.57–1.02) | 0.069 |
| rs915894 | 0.64 (0.50–0.83) | 5.6 × 10−4 | 0.61 (0.45–0.82) | 0.001 | 0.69 (0.51–0.92) | 0.012 |
| rs415929 | 1.24 (0.97–1.57) | 0.084 | 2.39 (1.82–3.13) | 1.8 × 10−10 | 1.38 (1.04–1.83) | 0.024 |
| rs520688 | 1.23 (0.97–1.57) | 0.092 | 2.26 (1.72–2.97) | 3.6 × 10−9 | 1.35 (1.02–1.79) | 0.039 |
| rs520692 | 1.23 (0.97–1.57) | 0.092 | 2.26 (1.72–2.97) | 3.6 × 10−9 | 1.35 (1.02–1.79) | 0.039 |
| rs520803 | 1.23 (0.97–1.58) | 0.092 | 2.26 (1.72–2.97) | 3.6 × 10−9 | 1.35 (1.02–1.80) | 0.039 |
| rs422951 | 0.95 (0.75–1.21) | 0.698 | 1.53 (1.15–2.02) | 0.0029 | 1.01 (0.77–1.34) | 0.935 |
| rs423023 | 1.12 (0.87–1.45) | 0.374 | 2.23 (1.67–2.97) | 4.3 × 10−8 | 1.24 (0.92–1.67) | 0.151 |
| rs204987 | 0.11 (0.03–0.35) | 8 × 10−6 | 0.45 (0.20–1.04) | 0.057 | 0.66 (0.32–1.37) | 0.263 |
| rs8192579 | 0.31 (0.18–0.60) | 2.5 × 10−4 | 1.52 (0.92–2.51) | 0.102 | 0.65 (0.35–1.23) | 0.187 |
| rs1044507 | 0.26 (0.10–0.65) | 0.002 | 0.31 (0.10–0.91) | 0.024 | 0.47 (0.19–1.18) | 0.1 |
| 10CTG | Reference | |||||
| 13CTG | 0.24 (0.09–0.6) | 1.6 × 10−3 | 0.33 (0.1–1.05) | 0.076 | 0.48 (0.19–1.21) | 0.161 |
| 12CTG | 0.67 (0.48–0.93) | 0.022 | 0.57 (0.34–0.94) | 0.036 | 0.66 (0.42–1.04) | 0.088 |
| 11CTG | 0.92 (0.67–1.26) | 0.658 | 2.84 (2.07–3.9) | 7.3 × 10−11 | 1.4 (0.97–2.02) | 0.085 |
| 9CTG | 0.52 (0.41–0.67) | 3.5 × 10−7 | 0.95 (0.7–1.28) | 0.783 | 0.87 (0.65–1.16) | 0.372 |
| 6CTG | 1.4 (1.06–1.84) | 0.019 | 1.17 (0.79–1.74) | 0.504 | 1.31 (0.91–1.89) | 0.172 |
| 5CTG | 0.92 (0.18–4.58) | 1 | 1.05 (0.13–8.78) | 1 | 1.85 (0.37–9.26) | 0.788 |