Table 3.

Association of NOTCH4 variants with SSc by allelic model in the Chinese cohort.

	SSc vs Control		ACA+ vs Control		ATA+ vs Control
SNP	OR	p	OR	p	OR	p
rs1044507	0.56 (0.40–0.79)	6.8 × 10⁻⁴	0.52 (0.29–0.95)	0.031	0.75 (0.29–1.89)	0.536
rs204987	2.50 (0.48–12.90)	0.258	2.04 (0.18–22.59)	0.552	0.00 (0.00–NaN)	0.713
rs415929	1.02 (0.84–1.25)	0.824	1.28 (0.94–1.74)	0.120	1.92 (1.16–3.17)	0.0099
rs422951	0.93 (0.76–1.13)	0.471	1.16 (0.85–1.58)	0.339	1.33 (0.79–2.24)	0.288
rs423023	1.03 (0.84–1.27)	0.774	1.27 (0.92–1.75)	0.139	1.75 (1.04–2.94)	0.033
rs443198	1.03 (0.88–1.22)	0.697	1.14 (0.87–1.48)	0.346	1.26 (0.79–2.02)	0.336
rs520688	1.03 (0.84–1.27)	0.788	1.28 (0.93–1.76)	0.127	1.78 (1.06–3.00)	0.028
rs520692	1.17 (0.93–1.47)	0.191	1.51 (1.08–2.12)	0.016	1.76 (1.00–3.11)	0.047
rs520803	1.16 (0.92–1.45)	0.213	1.49 (1.06–2.09)	0.020	1.74 (0.99–3.06)	0.053
rs8192579	1.07 (0.74–1.56)	0.719	1.20 (0.68–2.14)	0.525	1.67 (0.70–4.03)	0.245
rs915894	0.93 (0.78–1.09)	0.361	0.83 (0.64–1.09)	0.176	0.58 (0.35–0.95)	0.028
10CTG	Reference
13CTG	0.7 (0.48–1.03)	0.086	0.73 (0.38–1.43)	0.449	0.71 (0.24–2.13)	0.718
12CTG	0.82 (0.23–2.93)	1	1.79 (0.35–9.1)	0.822	0 (0–∞)	1
11CTG	1.21 (0.92–1.6)	0.194	1.43 (0.92–2.23)	0.141	0.81 (0.35–1.88)	0.777
9CTG	1.42 (1.15–1.75)	0.001	1.37 (0.96–1.95)	0.099	1.19 (0.67–2.14)	0.651
6CTG	1.67 (1.27–2.19)	3 × 10⁻⁴	2.05 (1.34–3.11)	0.001	1.21 (0.56–2.59)	0.773

SSc: systemic sclerosis; ACA: anticentromere antibodies; ATA: antibodies to topoisomerase I; SNP: single-nucleotide polymorphism.