Table 1.

Quality of evidence: Certainty in effect8.

Rating of Evidence QualityDefinition
HighWe are very confident that the true effect lies close to that of the estimate of the effect.
ModerateWe are moderately confident in the effect estimate. The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
LowOur confidence in the effect estimate is limited. The true effect may be substantially different from the estimate of the effect.
Very lowWe have very little confidence in the effect estimate. The true effect is likely to be substantially different from the estimate of effect.