Concomitant use of medications and supplements among persons with radiographically confirmed knee OA by the use of injections.
| Variables | Baseline | Index Year | One Year after Injection Initiation | ||||||
|---|---|---|---|---|---|---|---|---|---|
| CO | HA | Nonuser | CO | HA | Nonuser | CO | HA | Nonuser | |
| Use of analgesics | |||||||||
| Acetaminophen | 23.6 | 21.3 | 16.2 | 22.0 | 19.2 | 12.3 | 21.4 | 18.2 | 14.5 |
| NSAIDa | 35.2 | 39.4 | 31.5 | 37.3 | 42.6 | 28.3 | 38.4 | 40.9 | 27.7 |
| COX-2 inhibitors | 10.4 | 11.7 | 4.2 | 7.2 | 12.8 | 3.1 | 7.8 | 7.6 | 3.4 |
| Opioids | 9.4 | 8.5 | 8.7 | 12.9 | 11.7 | 6.9 | 14.8 | 12.1 | 8.1 |
| Any use of analgesics | 55.0 | 56.4 | 44.4 | 58.5 | 63.8 | 39.6 | 57.6 | 57.6 | 38.6 |
| 3+ | 4.7 | 8.5 | 1.9 | 3.5 | 5.3 | 1.7 | 5.8 | 6.1 | 2.0 |
| 2+ | 17.9 | 14.9 | 12.7 | 17.3 | 17.0 | 8.0 | 16.3 | 13.6 | 10.9 |
| Use of supplements | |||||||||
| Glucosamine | 30.8 | 48.9 | 27.1 | 34.6 | 44.7 | 25.9 | 26.9 | 36.4 | 21.8 |
| Chondroitin sulfate | 27.4 | 44.7 | 24.8 | 30.5 | 41.5 | 22.9 | 24.5 | 30.3 | 19.5 |
| Methylsulfonylmethane | 8.2 | 14.9 | 6.9 | 10.1 | 20.2 | 8.3 | 9.0 | 19.7 | 9.3 |
| S-adenosylmethionine | 0.3 | 1.1 | 0.4 | 0.9 | 0 | 0.5 | 0.8 | 0 | 0.5 |
| Other current prescribed medications | |||||||||
| Doxycycline | 0 | 0 | 0.5 | 0.3 | 0 | 0 | 0 | 0 | 0.2 |
| Vitamin D | 0.3 | 3.2 | 0.5 | 0.6 | 5.3 | 2.2 | 2.8 | 3.0 | 2.5 |
| Medications for osteoporosis | 11.0 | 7.5 | 8.0 | 8.8 | 7.5 | 7.1 | 7.4 | 4.6 | 6.1 |
Values are percentages.
↵a Including self-reported over-the-counter use and current prescriptions such as aspirin, ibuprofen, and salicylate. No. participants with missing information: At baseline — NSAID (29), doxycycline (27), Vitamin D (27). At index year — NSAID (31), doxycycline (26), Vitamin D (31). One year after injection initiation — NSAID (58), doxycycline (40), Vitamin D (43). NSAID: nonsteroidal antiinflammatory drugs; CO: corticosteroid; HA: hyaluronic acid; OA: osteoarthritis; COX: cyclooxygenase.