Associations between RF− RA and HLA-DRB1 alleles in comparison with healthy controls (HC).
| Constant RF−, n = 344 vs HC, n = 2008 | ||||
|---|---|---|---|---|
| Logistic Regression | ||||
| HLA-DRB1 Allele | AF of HC | AF of Cases | p | OR (95% CI) |
| *01:01 | 6.15 | 8.14 | 0.049 | 1.36 (1.00–1.84) |
| *04:01 | 1.12 | 1.74 | 0.18 | 1.54 (0.82–2.91) |
| *04:03 | 3.11 | 2.47 | 0.36 | 0.79 (0.47–1.31) |
| *04:05 | 11.68 | 16.28 | 8.1 × 10−4 | 1.46 (1.17–1.82) |
| *04:06 | 3.46 | 2.62 | 0.26 | 0.75 (0.45–1.24) |
| *04:07 | 0.50 | 0.44 | 0.81 | 0.86 (0.25–2.92) |
| *04:10 | 1.92 | 2.47 | 0.37 | 1.28 (0.62–2.62) |
| *08:02 | 4.51 | 4.07 | 0.65 | 0.91 (0.61–1.36) |
| *08:03 | 8.07 | 6.69 | 0.22 | 0.82 (0.59–1.13) |
| *09:01 | 14.59 | 14.39 | 0.90 | 0.99 (0.79–1.24) |
| *10:01 | 0.45 | 1.31 | 0.013 | 2.71 (1.24–5.93) |
| *11:01 | 2.54 | 1.45 | 0.092 | 0.57 (0.29–1.10) |
| *12:01 | 3.19 | 4.80 | 0.029 | 1.55 (1.05–2.30) |
| *12:02 | 1.44 | 2.18 | 0.14 | 1.54 (0.87–2.72) |
| *13:01 | 0.57 | 0.73 | 0.63 | 1.27 (0.48–3.38) |
| *13:02 | 8.09 | 4.07 | 2.7 × 10−4 | 0.48 (0.33–0.71) |
| *14:01 | 3.41 | 2.91 | 0.47 | 0.84 (0.52–1.35) |
| *14:03 | 1.32 | 2.03 | 0.14 | 1.56 (0.86–2.85) |
| *14:05 | 2.02 | 2.47 | 0.40 | 1.25 (0.75–2.09) |
| *14:06 | 1.15 | 1.89 | 0.12 | 1.65 (0.88–3.09) |
| *15:01 | 7.00 | 5.67 | 0.21 | 0.81 (0.57–1.13) |
| *15:02 | 12.0 | 7.99 | 0.0020 | 0.63 (0.47–0.84) |
| *16:02 | 0.87 | 1.02 | 0.67 | 1.19 (0.53–2.71) |
| SE | 21.34 | 30.09 | 7.4 × 10−7 | 1.57 (1.31–1.87) |