Variables | Univariate | Multivariate | ||||
---|---|---|---|---|---|---|
HR | 95% CI | p | HR | 95% CI | p | |
Clinical | ||||||
Age | 0.983 | 0.953–1.013 | 0.265 | |||
Female/male | 3.176 | 1.414–7.131 | 0.005 | 1.561 | 0.494–4.935 | 0.448 |
WBC count, 109/l | 1.146 | 1.018–1.29 | 0.024 | 1.034 | 0.888–1.205 | 0.665 |
Hemoglobin, g/l | 0.967 | 0.949–0.985 | < 0.001 | 0.970 | 0.947–0.992 | 0.009 |
Platelet, × 109/l | 0.999 | 0.994–1.004 | 0.705 | |||
C3, mg/dl | 0.993 | 0.972–1.014 | 0.500 | |||
C4, mg/dl | 1.035 | 0.981–1.093 | 0.204 | |||
Positive anti-dsDNA | 0.910 | 0.459–2.002 | 0.959 | |||
uPCR, g/g | 1.105 | 1.306–1.178 | 0.002 | 1.086 | 0.989–1.192 | 0.084 |
SCr, mg/dl | 1.920 | 1.613–2.285 | < 0.001 | 1.834 | 1.465–2.296 | < 0.001 |
Albumin, g/l | 0.935 | 0.882–0.992 | 0.027 | 0.967 | 0.899–1.040 | 0.372 |
Renal pathological characteristics | ||||||
Glomerular sclerosis, % | 1.036 | 1.012–1.061 | 0.003 | 1.031 | 0.998–1.066 | 0.065 |
Segmental crescents, % | 1.024 | 1.000–1.048 | 0.054 | |||
Cellular crescents, % | 1.043 | 1.025–1.060 | < 0.001 | 1.040 | 1.015–1.066 | 0.002 |
Fibrous crescents, % | 1.285 | 1.115–1.482 | 0.001 | 0.975 | 0.785–1.210 | 0.816 |
Fibrocellular crescents, % | 1.116 | 1.068–1.166 | < 0.001 | 1.085 | 1.013–1.163 | 0.020 |
Fibrinoid necrosis | 0.684 | 0.163–2.871 | 0.603 | |||
Mesangial proliferation | 0.616 | |||||
Mild | 0.400 | 0.052–3.100 | 0.380 | |||
Moderate | 0.452 | 0.054–3.778 | 0.464 | |||
Severe | 0.672 | 0.081–5.547 | 0.712 | |||
Podocyte fusion | 0.705 | |||||
Localized | 1667 | 0–4.4 × 108 | 0.936 | |||
Partial | 3455 | 0–9.2 × 108 | 0.930 | |||
Extensive | 3423 | 0–9.1 × 108 | 0.930 | |||
Thrombosis | 1.290 | 0.175–9.489 | 0.803 | |||
Tubulitis | 1.568 | 0.795–3.092 | 0.194 | |||
Tubular atrophy | < 0.001 | |||||
Mild | 1.945 | 0.765–4.949 | 0.162 | |||
Moderate | 7.045 | 1.339–37.064 | 0.021 | 1.200 | 0.01–15.739 | 0.890 |
Severe | 10.854 | 3.482–33.830 | < 0.001 | 5.348 | 1.278–22.373 | 0.022 |
Interstitial infiltration | 0.314 | |||||
Mild | 1.254 | 0.430–3.660 | 0.678 | |||
Moderate | 1.779 | 0.501–6.310 | 0.373 | |||
Severe | 5.019 | 0.899–28.032 | 0.066 | |||
Interstitial fibrosis | 0.102 | |||||
Mild | 1.380 | 0.556–3.427 | 0.487 | |||
Moderate | 3.027 | 0.395–23.218 | 0.287 | |||
Severe | 5.734 | 1.317–24.963 | 0.020 | 0.292 | 0.045–1.887 | 0.196 |
C1q | 0.468 | |||||
Mild | 0.308 | 0.069–1.382 | 0.124 | |||
Moderate | 0.609 | 0.198–1.896 | 0.392 | |||
Severe | 0.703 | 0.228–2.170 | 0.540 |
SCr: serum creatinine; ESRD: endstage renal disease; WBC: white blood cell; C3: complement factor 3; uPCR: urine protein creatinine ratio.