Associations with knee osteoarthritis in African Americans (p < 1 × 10−6).
| Marker | Nearest Gene(s) | Chr | Risk/Other Allele | Risk Allele Freq | JoCo* | OAI* | Metaanalysis, Adjusted for Age, Sex, and PC | Metaanalysis, Adjusted for Age, Sex, PC, and BMI | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |||||
| rs7792864 | LINC01006 | 7 | C / G | 0.88 | 2.21 (1.43–3.41) | 3.56 × 10−4 | 2.47 (1.69–3.60) | 2.79 × 10−6 | 2.35 (1.77–3.13) | 4.11 × 10−9 | 2.29 (1.69–3.10) | 1.02 × 10−7 |
| rs145965284 | MAGI1 | 3 | A / T | 0.27 | 1.72 (1.22–2.44) | 1.94 × 10−3 | 2.27 (1.54–3.33) | 2.78 × 10−5 | 1.96 (1.51–2.54) | 3.18 × 10−7 | 1.92 (1.46–2.53) | 3.12 × 10−6 |
| rs78571182 | ANKRD6 | 6 | T / G | 0.88 | 2.59 (1.70–3.94) | 9.69 × 10−6 | 1.74 (1.19–2.54) | 4.25 × 10−3 | 2.08 (1.57–2.75) | 3.70 × 10−7 | 2.17 (1.61–2.93) | 3.62 × 10−7 |
| rs76983122 | EPPK1/PLEC | 8 | T / C | 0.11 | 2.70 (1.75–4.35) | 1.00 × 10−5 | 1.89 (1.18–3.03) | 8.25 × 10−3 | 2.31 (1.67–3.20) | 4.90 × 10−7 | 2.27 (1.60–3.21) | 3.76 × 10−6 |
| rs4920343 | PAX7/TAS1R2 | 1 | G / A | 0.87 | 1.79 (1.20–2.70) | 4.73 × 10−3 | 2.17 (1.52–3.13) | 3.43 × 10−5 | 2.00 (1.52–2.63) | 6.82 × 10−7 | 2.04 (1.54–2.78) | 1.27 × 10−6 |
| rs9783397 | DDX10/C11orf87 | 11 | T / G | 0.71 | 2.21 (1.53–3.19) | 2.53 × 10−5 | 1.59 (1.17–2.18) | 3.35 × 10−3 | 1.83 (1.44–2.32) | 6.99 × 10−7 | 1.88 (1.46–2.43) | 1.00 × 10−6 |
↵* OR adjusted for age, sex, and population stratification. Chr: chromosome; Freq: frequency; JoCo: Johnston County Osteoarthritis Study; OAI: Osteoarthritis Initiative; PC: principal components; BMI: body mass index.