Variables | Description |
---|---|
Population | People with RA who have reached an appropriate target of therapy (e.g., low disease activity or remission) |
Intervention | Treatment tapering or withdrawal |
Comparison | Tapering/withdrawal versus continuing treatment; different strategies of tapering |
Outcome | Patients experiencing significant increases in core flare symptoms (pain, fatigue, stiffness) and effects (physical function, participation) for at least 7 days so as to indicate the need for consideration of retreatment |
Time | May vary by trial depending on level of symptoms at start, anticipated pharmacodynamics of drugs, and other factors |
Setting | Clinical trial |
RA: rheumatoid arthritis.