Table 4.

Predictors of severe infection in 186 patients with ANCA-associated vasculitis, as determined by Cox-regression analysis.

Predictors	Univariable Analyses			Multivariable Analyses
Predictors	HR	95% CI	p	HR	95% CI	p
Age at diagnosis, yrs	1.50	1.27–1.78	< 0.001	1.46	1.20–1.77	< 0.001
ESRD^*	1.59	0.91–2.78	0.1	0.99	0.46–2.13	0.9
Sex, men	1.40	0.91–2.13	0.1	1.30	0.81–2.08	0.2
S-creatinine, µmol/l	1.12	1.04–1.20	0.001	1.07	0.96–1.19	0.1
Hemoglobin	0.84	0.74–0.95	0.005	0.90	0.77–1.05	0.1
ENT involvement	0.60	0.39–0.94	0.02	0.95	0.54–1.66	0.9
Anti-PR3 positivity	0.91	0.58–1.42	0.6	1.14	0.66–1.98	0.6
Early cohort	0.88	0.56–1.36	0.5	0.79	0.47–1.33	0.7

↵* In this Cox-regression analysis, only patients in whom ESRD occurred before the infection event were included. ANCA: antineutrophil cytoplasmic antibody; ESRD: endstage renal disease; PR3: proteinase 3.