Table 1.

Clinical correlation of serum CXCL6 levels in patients with SSc. Statistical analysis was carried out with a Fisher’s exact probability test for the analysis of frequency. Values are median (interquartile range), n unless otherwise specified.

Clinical SymptomsSerum CXCL6 Levels, pg/mlp
Patients with SymptomsPatients without Symptoms
Interstitial lung disease93.9 (67.7–127.6), 3373.8 (39.4–94.4), 250.044
Esophageal dysfunction92.9 (64.3–111.6), 4170.5 (39.4–111.1), 170.29
Heart involvement101.1 (90.0–206.7), 1276.4 (49.1–99.9), 460.0049
Elevated RVSP100.6 (69.6–149.1), 1782.2 (42.7–96.2), 400.029
Raynaud phenomenon92.4 (64.8–123.7), 5048.7 (80.1–21.2), 80.015
Nailfold bleeding84.4 (62.2–100.6), 3987.9 (26.1–149.3), 190.93
DU/DPS101.3 (88.9–166.0), 2468.2 (38.2–94.4), 33< 0.0001
Telangiectasia94.7 (75.0–144.6), 3065.6 (26.0–97.4), 260.0032
  • Interstitial lung disease was defined as the presence of ground-glass opacity and/or reticular pattern on high-resolution computed tomography. Esophageal dysfunction was defined as distal esophageal hypomotility on barium-contrast radiography. Heart involvement was defined as any of the following: symptomatic pericarditis, clinical evidence of left ventricular congestive heart failure, or arrhythmias requiring treatment. Elevated RVSP was defined as 35 mmHg or more on echocardiogram. DU are defined as a loss of epithelialization and tissues involving, in different degrees, the epidermis, the dermis, the subcutaneous tissue, and sometimes also involving the bone. DPS are defined as small-sized hyperkeratosis. RVSP: right ventricular systolic pressure; DU: digital ulcers; DPS: digital pitting scars.