Table 1.

Frequency of ILA, VVV, and SVV and their respective PPV for diagnosis of GCA or GCA/PMR. The results are given for findings by at least 1 of the 2 pathologists or both. κ values express the interpathologist concordance for specific findings.

Variableκ (95% CI)GCA, n = 8, vs Non-GCA, n = 67GCA/PMR, n = 15, vs Non-GCA/PMR, n = 60
FrequencyPPV % (95% CI)FrequencyPPV % (95% CI)
Any infiltrate
  ILA0.63 (0.42–0.84)
    Either pathologist2/8 vs 10/6717 (2–48)4/15 vs 8/6033 (10–65)
    Both pathologists1/8 vs 5/6717 (0–64)1/15 vs 5/6017 (0–64)
  VVV0.21 (−0.01 to 0.43)
    Either pathologist0/8 vs 7/670 (0–41)0/15 vs 7/600 (0–41)
    Both pathologists0/8 vs 1/670 (0–98)0/15 vs 1/600 (0–98)
  SVV0.35 (0.14–0.57)
    Either pathologist2/8 vs 27/677 (1–23)7/15 vs 22/6024 (10–44)
    Both pathologists1/8 vs 9/6710 (0–45)4/15 vs 6/6040 (12–74)
  ILA, VVV, and/or SVV0.50 (0.29–0.72)
    Either pathologist2/8 vs 29/676 (1–21)7/15 vs 24/6023 (10–41)
    Both pathologists2/8 vs 13/6713 (2–40)5/15 vs 10/6033 (12–62)
Infiltrate ≥ 15 cells
  ILA0.57 (0.35–0.79)
    Either pathologist1/8 vs 6/6714 (0–58)1/15 vs 6/6014 (0–58)
    Both pathologists1/8 vs 2/6733 (1–100)1/15 vs 2/6033 (1–91)
  VVV0 (NC)
    Either pathologist0/8 vs 1/670 (0–98)0/15 vs 1/600 (0–98)
    Both pathologists0/8 vs 0/67NC0/15 vs 0/60NC
  SVV0.25 (0.10–0.40)
    Either pathologist1/8 vs 16/676 (0–29)3/15 vs 14/6018 (4–43)
    Both pathologists1/8 vs 2/6733 (1–100)2/15 vs 1/6067 (9–100)
  ILA, VVV, and/or SVV0.39 (0.21–0.57)
    Either pathologist1/8 vs 16/676 (0–29)3/15 vs 14/6018 (4–43)
    Both pathologists1/8 vs 4/6720 (1–72)2/15 vs 3/6040 (5–85)
  • ILA: inflammation limited to the adventitia; VVV: vasa vasorum vasculitis; SVV: small-vessel vasculitis; PPV: positive predictive values; GCA: giant cell arteritis; PMR: polymyalgia rheumatica; NC: not calculable.