Characteristics of the 11 patients with antisynthetase syndrome complicated with rapidly progressive interstitial lung disease.
| Patient | Age, Yrs/sex | Antisynthetase Antibodies | BALF Findings, % | Serum Ferritin, ng/ml | Anti-Ro52 Antibody | CT Scan Pattern | Outcomes | ||
|---|---|---|---|---|---|---|---|---|---|
| Lymphocytes | Neutrophils | Macrophagocytes | |||||||
| 1 | 64/F | Jo1 | 6.8 | 81.2 | 6.5 | 208.8 | − | NSIP | Improved in 1 mo |
| 2 | 70/M | Jo1 | ND | ND | ND | ND | − | UIP | Died |
| 3 | 67/F | Jo1 | ND | ND | ND | ND | − | OP | Died |
| 4 | 28/F | PL7 | 1.0 | 63.5 | 31.5 | 169.1 | + | OP | Improved in 2 mos |
| 5 | 56/M | PL7 | 9.5 | 57.8 | 31.7 | 2000.0 | + | ND | Died |
| 6 | 48/F | PL7 | 6.5 | 69.7 | 20.5 | 933.5 | + | NSIP | Died |
| 7 | 69/M | PL7 | 0 | 96.3 | 3.7 | 1716.0 | + | NSIP | Died |
| 8 | 32/F | PL7 | 73 | 7.8 | 7.5 | 77.5 | + | OP | Improved in 2 mos |
| 9 | 74/F | PL7 | ND | ND | ND | ND | + | NSIP | Died |
| 10 | 48/F | PL12 | ND | ND | ND | 1510.0 | + | OP | Improved in 10 days |
| 11 | 44/F | EJ | 0.3 | 92.5 | 7.2 | 1138.2 | + | NSIP | Improved in 2 mos |
BALF: bronchoalveolar lavage fluid; CT: computed tomography; NSIP: nonspecific interstitial pneumonia; UIP: usual interstitial pneumonia; OP: organizing pneumonia; ND: no data.