Baseline characteristics of participants. For readability, the SD are not specified. Within each study, patient characteristics at baseline did not differ between the 2 treatment groups. There were differences between cohorts: the RACAT cohort included older men with RA and a higher percentage of seropositive patients with RA in the TEAR cohort.
| Study | No. Randomized Patients | Age, Yrs, Mean | Female, % | Symptom Duration, Mos | RF-positive, % | DAS28 | HAQ | Total Sharp Score, Mean* | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TT | Anti-TNF-α + MTX | TT | Anti-TNF-α + MTX | TT | Anti-TNF-α + MTX | TT | Anti-TNF-α + MTX | TT | Anti-TNF-α + MTX | TT | Anti-TNF-α + MTX | TT | Anti-TNF-α + MTX | TT | Anti-TNF-α + MTX | |
| O’Dell, et al16 (RACAT) | 178 | 175 | 57.8 | 56 | 43.3 | 48.6 | 66 | 60 | 65.7 | 66.9 | 5.8 | 5.9 | 1.4 | 1.5 | 20.4 | 16.3 |
| Moreland, et al6 (TEAR) | ||||||||||||||||
| Initial treatment | 132 | 244 | 48.8 | 50.7 | 76.5 | 74.2 | 4.1 | 3.5 | 91.7 | 88.5 | 5.8 | 5.8 | 1 | 1.1 | 6.9 | 6.8 |
| Step-up treatment | 124 | 255 | 49.3 | 48.6 | 70.2 | 69 | 4.5 | 2.9 | 87.1 | 91 | 5.8 | 5.8 | 1 | 1 | 7.2 | 4.4 |
| van Vollenhoven, et al18 (SWEFOT) | 130 | 128 | 52.9 | 51.1 | 78 | 76 | 6.3 | 6.2 | 65 | 69 | 5.98 | 5.91 | 1.32 | 1.27 | 5.5 | 4.6 |
| Heimans, et al17 (IMPROVED) | 83 | 78 | 49 | 51 | 77 | 74 | 5.5 | 5.3 | 49 | 55 | 3.6 | 3.6 | 1.4 | 1.4 | 0** | 0** |