Predictive significance of AFA for mortality in the multivariable model.
| Variable | HR | 95% CI | p |
|---|---|---|---|
| AFA positivity | 1.88 | 1.19–2.97 | 0.007 |
| Female | 0.49 | 0.35–0.68 | < 0.001 |
| Ethnicity | |||
| White | 1 | 1–1 | 1 |
| African descent | 2.05 | 1.25–3.36 | 0.005 |
| Latino | 1.34 | 0.81–2.22 | 0.26 |
| Asian | 1.15 | 0.54–2.47 | 0.717 |
| Native North American | 1.04 | 0.50–2.16 | 0.924 |
| Australian aboriginal* | 15.78 | 2.15–115.58 | 0.007 |
| Age at enrollment, yrs | 1.02 | 1.01–1.04 | < 0.001 |
| Site | |||
| GENISOS | 2.6 | 1.78–3.8 | < 0.001 |
| ASCS | 1.27 | 0.60–2.66 | 0.534 |
↵* No AFA-positive patients in this ethnic group. AFA: antifibrillarin antibodies; GENISOS: Genetics versus Environment in Scleroderma Outcome Study; ASCS: Australian Scleroderma Cohort Study.