Correlations between interleukin 33 (IL-33) and soluble ST2 levels and those of disease activity markers in 40 patients with adult-onset Still’s disease.
| Disease Activity Marker | Pearson’s Correlation Coefficients, r (p) | |
|---|---|---|
| IL-33 | Soluble ST2 | |
| Systemic score | 0.476 (0.002) | −0.014 (0.931) |
| Leukocyte | 0.060 (0.713) | −0.067 (0.683) |
| Hemoglobin | −0.103 (0.528) | −0.210 (0.194) |
| Platelet | −0.009 (0.955) | −0.011 (0.946) |
| ESR | 0.530 (< 0.001) | 0.186 (0.251) |
| CRP | 0.208 (0.197) | 0.016 (0.924) |
| Ferritin | 0.333 (0.036) | 0.379 (0.016) |
| LDH | 0.095 (0.560) | 0.003 (0.986) |
| Albumin | −0.043 (0.791) | −0.246 (0.126) |
| Bilirubin | −0.237 (0.142) | −0.093 (0.570) |
| AST | 0.335 (0.035) | 0.11 (0.498) |
| ALT | 0.231 (0.151) | −0.151 (0.354) |
| Soluble ST2 | 0.079 (0.626) | — |
The systemic scoring system of Pouchot, et al21 assigns a score from 0 to 12, with 1 point for each of the following manifestations: fever, typical rash, pleuritis, pneumonia, pericarditis, hepatomegaly or abnormal liver function test data, splenomegaly, lymphadenopathy, leukocytosis ≥ 15,000/mm2, sore throat, myalgia, and abdominal pain. ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; LDH: lactate dehydrogenase; AST: aspartate transaminase; ALT: alanine transaminase.