Table 3B.

Association between disability (HAQ) and DAS28, pain, ES, and JSN, from 1 year to the 8-year followup with GEE and multivariate model, controlled for sex, age, RF, and smoking habit for the separate cohorts.

Variables	Cohort 1			Cohort 2
Variables	β	95% CI	p	β	95% CI	p
DAS28	0.218	0.200–0.235	< 0.001	0.244	0.226–0.262	< 0.001
Female	0.095	0.038–0.152	0.001	0.175	0.120–0.229	< 0.001
Age, yrs	0.002	0.000–0.004	0.087	0.004	0.003–0.006	< 0.001
RF	−0.057	−0.116 to 0.001	0.056	−0.021	−0.076 to 0.035	0.461
Smoker	0.022	−0.046 to 0.090	0.528	0.101	0.031–0.170	0.004
Previous smoker	0.014	−0.052 to 0.079	0.678	0.033	−0.030 to 0.097	0.301
Pain	0.014	0.013–0.015	< 0.001	0.015	0.0134–0.016	< 0.001
Female	0.150	0.098–0.202	< 0.001	0.180	0.131–0.229	< 0.001
Age, yrs	0.003	0.000–0.005	0.039	0.006	0.004–0.008	< 0.001
RF	−0.021	−0.074 to 0.032	0.793	0.022	−0.029 to 0.072	0.401
Smoker	0.019	−0.044 to 0.083	0.548	0.088	0.023–0.152	0.008
Previous smoker	−0.002	−0.063 to 0.058	0.943	0.021	−0.036 to 0.079	0.470
ES	0.006	0.003–0.009	< 0.001	0.003	−0.002 to 0.008	0.305
Female	0.240	0.172–0.308	< 0.001	0.311	0.243–0.378	< 0.001
Age, yrs	0.003	0.000–0.005	0.025	0.006	0.004–0.008	< 0.001
RF	−0.035	−0.108 to 0.038	0.346	0.026	−0.043 to 0.095	0.458
Smoker	0.057	−0.027 to 0.141	0.185	0.121	0.033–0.208	0.007
Previous smoker	0.022	−0.059 to 0.104	0.588	0.054	−0.024 to 0.132	0.177
JSN	0.005	0.003–0.008	< 0.001	0.005	0.002–0.007	< 0.001
Female	0.231	0.162–0.299	< 0.001	0.298	0.230–0.365	< 0.001
Age, yrs	0.002	0.000–0.005	0.106	0.005	0.003–0.007	< 0.001
RF	−0.037	−0.109 to 0.035	0.318	0.018	−0.051 to 0.088	0.606
Smoker	0.057	−0.027 to 0.140	0.183	0.120	0.033–0.208	0.007
Previous smoker	0.024	−0.057 to 0.105	0.560	0.059	−0.018 to 0.136	0.136

Significant data are in bold face. DAS28: 28-joint Disease Activity Score; RF: rheumatoid factor; ES: erosion score; JSN: joint space narrowing; HAQ: Health Assessment Questionnaire; GEE: generalized estimating equation.